rs76992529(A;A)
From SNPedia
| TTR-related cardiac amyloidosis |
| Is a | genotype |
| of | rs76992529 |
| Gene | TTR |
| Chromosome | 18 |
| Position | 31,598,655 |
| Merged from | Rs28933980 |
| mentioned | by |
| Magnitude | 5 |
| Repute | Bad |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 5 | TTR-related cardiac amyloidosis |
| (A;G) | 5.5 | TTR-related amyloidosis |
| (G;G) | 0 | common in clinvar |
A person with one or two copies of the (A) allele of this SNP is at significantly higher (by about 2 - 3 fold) risk of developing cardiac amyloidosis, in which levels of the transthyretin protein build up and may lead to heart failure, especially with increasing age.
