rs7759938

plus

Geno	Mag	Summary
(C;C)		age at menarche ~2 months later on average
(C;T)		age at menarche ~1 month later on average
(T;T)		normal

Reference

GRCh38 38.1/141

Chromosome

6

Position

104931079

is a	snp
is	mentioned by
dbSNP	rs7759938
dbSNP (classic)	rs7759938
ClinGen	rs7759938
ebi	rs7759938
HLI	rs7759938
Exac	rs7759938
Gnomad	rs7759938
Varsome	rs7759938
LitVar	rs7759938
Map	rs7759938
PheGenI	rs7759938
Biobank	rs7759938
1000 genomes	rs7759938
hgdp	rs7759938
ensembl	rs7759938
geneview	rs7759938
scholar	rs7759938
google	rs7759938
pharmgkb	rs7759938
gwascentral	rs7759938
openSNP	rs7759938
23andMe	rs7759938
SNPshot	rs7759938
SNPdbe	rs7759938
MSV3d	rs7759938
GWAS Ctlg	rs7759938

GMAF

0.3893

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

rs7759938 is a SNP from chromosomal region 6q21 showing a strong association with age at menarche in a study of 17,500 Icelandic women.

Per copy carried of the rs7759938(T) allele, age at menarche is delayed about 1 month.

GWAS snp
PMID	[PMID 19448620 ]
Trait	Menarche
Title	Meta-analysis of genome-wide association data identifies two loci influencing age at menarche
Risk Allele	C
P-val	7E-9
Odds Ratio	0.09 [0.05-0.13] years older

GWAS snp
PMID	[PMID 21102462 ]
Trait
Title	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
Risk Allele	C
P-val	5E-60
Odds Ratio	6.4000 [5.62-7.18] week increase

OMIM	606255
Desc
Variant
Related	also

OMIM	612882
Desc
Variant
Related	also

[PMID 22822098] Functional Study of Risk Loci of Stem Cell-associated Gene Lin-28B and Associations with Disease Survival Outcomes in Epithelial Ovarian Cancer

[PMID 20398887 ] Distinct variants at LIN28B influence growth in height from birth to adulthood.

[PMID 23152804 ] Association of LIN28B with Adult Adiposity-Related Traits in Females

GWAS snp
PMID	[PMID 20881960 ]
Trait	Height
Title	Hundreds of variants clustered in genomic loci and biological pathways affect human height.
Risk Allele	T
P-val	8E-31
Odds Ratio	.05 [NR] unit decrease

GWAS snp
PMID	[PMID 23449627 ]
Trait	Pubertal anthropometrics
Title	Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
Risk Allele	C
P-val	4E-9
Odds Ratio	.11 [0.079-0.141] unit increase

[PMID 23740805 ] Replication of LIN28B SNP association with age of menarche in young Filipino women

[PMID 29073238 ] Genetic variations, reproductive aging, and breast cancer risk in African American and European American women: The Women's Circle of Health Study.

[PMID 33552117 ] Candidate Genes for Age at Menarche Are Associated With Uterine Leiomyoma.