rs7775
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | |
| (G;G) | 0 |
| Make rs7775(C;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 182834857 |
| Gene | FRZB |
| is a | snp |
| is | mentioned by |
| dbSNP | rs7775 |
| dbSNP (classic) | rs7775 |
| ClinGen | rs7775 |
| ebi | rs7775 |
| HLI | rs7775 |
| Exac | rs7775 |
| Gnomad | rs7775 |
| Varsome | rs7775 |
| LitVar | rs7775 |
| Map | rs7775 |
| PheGenI | rs7775 |
| Biobank | rs7775 |
| 1000 genomes | rs7775 |
| hgdp | rs7775 |
| ensembl | rs7775 |
| geneview | rs7775 |
| scholar | rs7775 |
| rs7775 | |
| pharmgkb | rs7775 |
| gwascentral | rs7775 |
| openSNP | rs7775 |
| 23andMe | rs7775 |
| SNPshot | rs7775 |
| SNPdbe | rs7775 |
| MSV3d | rs7775 |
| GWAS Ctlg | rs7775 |
| GMAF | 0.1134 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs7775 (R324G) osteoarthritis at multiple joints (p = 0.07), particularly in the hip in women [PMID 17237116
]
associated with osteoarthritis of the hip in females
This is an arg324-to-gly (R324G) substitution
[PMID 19479880] Meta-analysis of 14 studies did not support a significant association between rs7775 and osteoarthritis.
[PMID 22095095] Variant alleles of the WNT antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis
| ClinVar | |
|---|---|
| Risk | rs7775(A;A) Rs7775(G;G) rs7775(T;T) |
| Alt | rs7775(A;A) Rs7775(G;G) rs7775(T;T) |
| Reference | Rs7775(C;C) |
| Significance | Other |
| Disease | Osteoarthritis susceptibility 1 |
| Variation | info |
| Gene | FRZB |
| CLNDBN | Osteoarthritis susceptibility 1 |
| Reversed | 1 |
| HGVS | NC_000002.11:g.183699584G>C |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000005530.2, |
[PMID 15210948] Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.
[PMID 18787887] Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.
[PMID 20043861] No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.
[PMID 22544526] Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.
[PMID 23516639] Association of single nucleotide polymorphisms in wnt signaling pathway genes with breast cancer in saudi patients
