rs8007267
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common/normal |
| Make rs8007267(C;T) |
| Make rs8007267(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 14 |
| Position | 54912273 |
| Gene | GCH1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs8007267 |
| dbSNP (classic) | rs8007267 |
| ClinGen | rs8007267 |
| ebi | rs8007267 |
| HLI | rs8007267 |
| Exac | rs8007267 |
| Gnomad | rs8007267 |
| Varsome | rs8007267 |
| LitVar | rs8007267 |
| Map | rs8007267 |
| PheGenI | rs8007267 |
| Biobank | rs8007267 |
| 1000 genomes | rs8007267 |
| hgdp | rs8007267 |
| ensembl | rs8007267 |
| geneview | rs8007267 |
| scholar | rs8007267 |
| rs8007267 | |
| pharmgkb | rs8007267 |
| gwascentral | rs8007267 |
| openSNP | rs8007267 |
| 23andMe | rs8007267 |
| SNPshot | rs8007267 |
| SNPdbe | rs8007267 |
| MSV3d | rs8007267 |
| GWAS Ctlg | rs8007267 |
| GMAF | 0.2874 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. T allele associated with higher tolerance to pain.[PMID 17057711]
Do genetic predictors of pain sensitivity associate with persistent widespread pain? T allele associated with higher pain tolerance.[PMID 19775452
]
GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Part of a haplotype, also defined by genosets gs223 and gs224, rs10483639(C)-rs3783641(A)-rs8007267(T), associated with lower levels of tetrahydrobiopterin.[PMID 18598896]
[PMID 17343757] Lack of influence of GTP cyclohydrolase gene (GCH1) variations on pain sensitivity in humans.
[PMID 17363416] Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms.
[PMID 19014702] Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
[PMID 19081190] Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain.
[PMID 19751821] Oxidative risk for atherothrombotic cardiovascular disease.
[PMID 20633294] Different SNP combinations in the GCH1 gene and use of labor analgesia.
[PMID 20842020] Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.
[PMID 23059057] A GCH1 haplotype and risk of neural tube defects in the National Birth Defects Prevention Study
[PMID 22770721] GTP cyclohydrolase 1 gene haplotypes as predictors of SSRI response in Japanese patients with major depressive disorder
