rs8034191

plus

Geno	Mag	Summary
(C;C)	2.6	1.80x lung cancer risk; decreased response to alcohol
(C;T)	2.5	1.27x lung cancer risk
(T;T)		normal

Reference

GRCh38 38.1/141

Chromosome

15

Position

78513681

Gene

HYKK

is a	snp
is	mentioned by
dbSNP	rs8034191
dbSNP (classic)	rs8034191
ClinGen	rs8034191
ebi	rs8034191
HLI	rs8034191
Exac	rs8034191
Gnomad	rs8034191
Varsome	rs8034191
LitVar	rs8034191
Map	rs8034191
PheGenI	rs8034191
Biobank	rs8034191
1000 genomes	rs8034191
hgdp	rs8034191
ensembl	rs8034191
geneview	rs8034191
scholar	rs8034191
google	rs8034191
pharmgkb	rs8034191
gwascentral	rs8034191
openSNP	rs8034191
23andMe	rs8034191
SNPshot	rs8034191
SNPdbe	rs8034191
MSV3d	rs8034191
GWAS Ctlg	rs8034191

GMAF

0.2084

Max Magnitude

2.6

?

(C;C) (C;T) (T;T)

28

23andMe blog rs8034191(C;C) decreased response to alcohol

Rs8034191
PubMed	[PMID 18385738]
Affy Probeset	SNP_A-8656206
Affy Orientation	reverse
On GW 5.0
Alleles A/B	A/G
Ancestral	T
Population	Caucasian(Europe)
Allele	C
Case Freq.	0.41
Control Freq.	0.34
Odds Ratio Het	1.27
Odds Ratio Hom	1.80
Odds Ratio All	1.32
Disease	Lung cancer (LC)

rs8034191 increases susceptibility to Lung cancer 1.27 times for heterozygotes (CT) and 1.80 times for homozygotes (CC) [PMID 18385738]

rs8034191 increases susceptibility to Lung cancer 1.28 times for heterozygotes (CT) and 1.81 times for homozygotes (CC) [PMID 18385676 ]

GWAS
SNP	rs8034191
PubMedID	[PMID 18385738]
Condition	Lung cancer
Gene	CHRNA3,CHRNA5, CHRNB4, PSMA4, LOC123688
Risk Allele	C
pValue	5.00E-020
OR	1.3
95% CI	1.23-1.37

[PMID 19300482 ] A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci.

GWAS snp
PMID	[PMID 18780872 ]
Trait	Lung cancer
Title	Familial Aggregation of Common Sequence Variants on 15q24-25.1 in Lung Cancer
Risk Allele	G
P-val	1E-8
Odds Ratio	1.38 [1.17-1.64]

[PMID 19465454] The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung

OMIM	612052
Desc	LUNG CANCER SUSCEPTIBILITY 2; LNCR2
Variant
Related	also

[PMID 19641473 ] Racial Differences in the Association Between SNPs on 15q25.1, Smoking Behavior, and Risk of Non-small Cell Lung Cancer

[PMID 19654303 ] Deciphering the Impact of Common Genetic Variation on Lung Cancer Risk: A Genome-Wide Association Study

[PMID 19733931] Blood-based CHRNA3 single nucleotide polymorphism and outcome in advanced non-small-cell lung cancer patients

[PMID 20056643 ] A rigorous and comprehensive validation: common genetic variations and lung cancer

[PMID 20068085 ] Analysis of Genetic Variants in Never-Smokers with Lung Cancer Facilitated by an Internet-Based Blood Collection Protocol: A Preliminary Report

[PMID 20554942 ] Nicotinic Acetylcholine Receptor Region on Chromosome 15q25 and Lung Cancer Risk Among African Americans: A Case-Control Study

[PMID 21750227] Single-nucleotide polymorphisms (5p15.33, 15q25.1, 6p22.1, 6q27 and 7p15.3) and lung cancer survival in the European Prospective Investigation into Cancer and Nutrition (EPIC)

[PMID 21966413 ] Smoking related cancers and loci at chromosomes 15q25, 5p15, 6p22.1 and 6p21.33 in the Polish population

[PMID 18759969 ] In search of causal variants: refining disease association signals using cross-population contrasts.

[PMID 18957677 ] The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer.

[PMID 19029397 ] Nicotinic receptor gene variants influence susceptibility to heavy smoking.

[PMID 19064933 ] Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.

[PMID 19247474 ] Genome-wide and candidate gene association study of cigarette smoking behaviors.

[PMID 19259974 ] Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

[PMID 19300500 ] A genome-wide association study of pulmonary function measures in the Framingham Heart Study.

[PMID 19474294 ] Potential etiologic and functional implications of genome-wide association loci for human diseases and traits.

[PMID 19639606 ] Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

[PMID 19706762 ] The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

[PMID 19800047 ] Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene.

[PMID 19836008 ] A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.

[PMID 20010835 ] Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.

[PMID 20548021 ] Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.

[PMID 21081471 ] Genetic variations on chromosomes 5p15 and 15q25 and bladder cancer risk: findings from the Los Angeles-Shanghai bladder case-control study.

[PMID 21232152 ] Epidemiology, radiology, and genetics of nicotine dependence in COPD.

[PMID 21320324 ] The role of IREB2 and transforming growth factor beta-1 genetic variants in COPD: a replication case-control study.

[PMID 21697764 ] Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer.

[PMID 21810735] Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada.

[PMID 22017462] Alpha-nicotinic acetylcholine receptor and tobacco smoke exposure: effects on bronchial hyperresponsiveness in children.

[PMID 22028403 ] A case-control study of a sex-specific association between a 15q25 variant and lung cancer risk.

[PMID 22701590 ] Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis

[PMID 24254305] Quantitative assessment of the influence of common variations (rs8034191 and rs1051730) at 15q25 and lung cancer risk

[PMID 22914670] Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population.

[PMID 23299987 ] Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility.

[PMID 25051068 ] Four SNPs in the CHRNA3/5 Alpha-Neuronal Nicotinic Acetylcholine Receptor Subunit Locus Are Associated with COPD Risk Based on Meta-Analyses

[PMID 25074529] Genetic Association Between AGPHD1 Variant and Lung Cancer Risk

[PMID 25854352] Meta-Analysis of the Association between the rs8034191 Polymorphism in AGPHD1 and Lung Cancer Risk