rs821616
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | cognitive decline in older women | |
| (A;T) | ? | |
| (T;T) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 1 |
| Position | 232008852 |
| Gene | DISC1, TSNAX-DISC1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs821616 |
| dbSNP (classic) | rs821616 |
| ClinGen | rs821616 |
| ebi | rs821616 |
| HLI | rs821616 |
| Exac | rs821616 |
| Gnomad | rs821616 |
| Varsome | rs821616 |
| LitVar | rs821616 |
| Map | rs821616 |
| PheGenI | rs821616 |
| Biobank | rs821616 |
| 1000 genomes | rs821616 |
| hgdp | rs821616 |
| ensembl | rs821616 |
| geneview | rs821616 |
| scholar | rs821616 |
| rs821616 | |
| pharmgkb | rs821616 |
| gwascentral | rs821616 |
| openSNP | rs821616 |
| 23andMe | rs821616 |
| SNPshot | rs821616 |
| SNPdbe | rs821616 |
| MSV3d | rs821616 |
| GWAS Ctlg | rs821616 |
| GMAF | 0.2484 |
| Max Magnitude | 0 |
| ? | (A;A) (A;T) (T;T) | 28 |
|---|---|---|
|
| ||
Women with two rs821616(T) SNPs seem to experience more rapid cognitive decline as they age compared to men. [PMID 16054297]
[PMID 17673452] 13 single-nucleotide polymorphisms (SNPs) in 723 members of 179 Finnish Bipolar disorder families.
- rs821616 verbal fluency
[PMID 19805229
] DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms
[PMID 21878470] Effect of DISC1 on the P300 Waveform in Psychosis
[PMID 22673686] Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population
[PMID 15386212] Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.
[PMID 15939883] Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia.
[PMID 17286247] Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population.
[PMID 17997036] Association study of polymorphisms between DISC1 and schizophrenia in a Korean population.
[PMID 18072279] Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA.
[PMID 19188535] Association of variants in DISC1 with psychosis-related traits in a large population cohort.
[PMID 19300510] The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes.
[PMID 19414483] The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations.
[PMID 20403199] High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta.
[PMID 20531374] Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.
[PMID 23140672] DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study
[PMID 23602339] Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.
[PMID 25670952] Disrupted-in-Schizophrenia-1 SNPs and Susceptibility to Schizophrenia: Evidence from Malaysia
[PMID 26945459] Association study of DISC1 genetic variants with the risk of schizophrenia.
[PMID 29945223] The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study.
[PMID 30286368] Association on DISC1 SNPs with schizophrenia risk: A meta-analysis.
