rs838133

Odds preferring sweet snack

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(C;C)	1.1	Lower odds of preferring candy or sweet snacks
(C;T)	1.2	Sweeth tooth tendency; slightly higher odds of preferring candy
(T;T)	1.4	Sweet Tooth; Higher odds of preferring candy

Reference

GRCh38 38.1/141

Chromosome

19

Position

48756272

Gene	FGF21, FUT1

is a	snp
is	mentioned by
dbSNP	rs838133
dbSNP (classic)	rs838133
ClinGen	rs838133
ebi	rs838133
HLI	rs838133
Exac	rs838133
Gnomad	rs838133
Varsome	rs838133
LitVar	rs838133
Map	rs838133
PheGenI	rs838133
Biobank	rs838133
1000 genomes	rs838133
hgdp	rs838133
ensembl	rs838133
geneview	rs838133
scholar	rs838133
google	rs838133
pharmgkb	rs838133
gwascentral	rs838133
openSNP	rs838133
23andMe	rs838133
SNPshot	rs838133
SNPdbe	rs838133
MSV3d	rs838133
GWAS Ctlg	rs838133

GMAF

0.2525

Max Magnitude

1.4

?	(C;C) (C;T) (T;T)	28

GWAS snp
PMID	[PMID 23372041]
Trait	Dietary macronutrient intake
Title	Novel locus including FGF21 is associated with dietary macronutrient intake.
Risk Allele	A
P-val	8E-9
Odds Ratio	.11 [0.071-0.149] percent decrease

GWAS snp
PMID	[PMID 23824729]
Trait	Homocysteine levels
Title	Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.
Risk Allele	A
P-val	7E-9
Odds Ratio	.04 [0.028-0.056] unit increase

A 2017 study of ~6,500 individuals with detailed eating records concluded that the rs838133(T) allele (in SNPedia and dbSNP orientation) increased the odds ratio (OR) of being in the top 33% of people for total intake of all types of sweet-tasting foods, with an OR of 1.18 per T-allele (CI: 1.06–1.32, p = 0.003). When sweet intake was divided into “candy” and “cake,” individuals carrying the T-allele had higher candy intake (OR 1.19, CI: 1.07–1.32, p = 0.0007), whereas intake of cake was the same regardless of rs838133 genotype. [PMID 28467924]

“Genetic associations with traits in 23andMe customers.” 23andMe White Paper.

Salty or sweet - 23andMe blog entry