rs925489

Orientation

plus

Stabilized

plus

Make rs925489(C;C)

Make rs925489(C;T)

Make rs925489(T;T)

Reference

GRCh38 38.1/141

Chromosome

9

Position

97784318

is a	snp
is	mentioned by
dbSNP	rs925489
dbSNP (classic)	rs925489
ClinGen	rs925489
ebi	rs925489
HLI	rs925489
Exac	rs925489
Gnomad	rs925489
Varsome	rs925489
LitVar	rs925489
Map	rs925489
PheGenI	rs925489
Biobank	rs925489
1000 genomes	rs925489
hgdp	rs925489
ensembl	rs925489
geneview	rs925489
scholar	rs925489
google	rs925489
pharmgkb	rs925489
gwascentral	rs925489
openSNP	rs925489
23andMe	rs925489
SNPshot	rs925489
SNPdbe	rs925489
MSV3d	rs925489
GWAS Ctlg	rs925489

GMAF

0.2254

Max Magnitude

0

?	(C;C) (C;T) (T;T)	28

Highest association to hypothyroidism in 23andMe cohort based [PMID 22493691], association found also in the first hypothyroidism GWAS [PMID 21981779]. It is 69kb upstream of the gene FOXE1 Forkhead Box E1 which is also known as TTF-2 Thyroid Transcription Factor 2, whose expression it affects according to the first study. In the more recent study, it had an odds ratio of 0.78 with a p-value of 2.4*10-19, meaning the minor allele C is protective. In the first study the C allele was also found associated with lower Serum thyroid-stimulating hormone levels, and homozygous CC allele potentially associated with Papillary Thyroid Cancer.

[PMID 24852370] Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.

[PMID 22493691] Novel associations for hypothyroidism include known autoimmune risk Loci

[PMID 21981779] Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.

GWAS snp
PMID	[PMID 24852370]
Trait	Serum thyroid-stimulating hormone levels
Title	Genome-wide association study identifies a novel susceptibility gene for serum TSH levels in Chinese populations.
Risk Allele	C
P-val	1E-13
Odds Ratio	.06 [NR] unit decrease