rs9465871
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.2x risk type-2 diabetes | |
| (C;T) | 1.2x risk type-2 diabetes | |
| (T;T) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 20717024 |
| Gene | CDKAL1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs9465871 |
| dbSNP (classic) | rs9465871 |
| ClinGen | rs9465871 |
| ebi | rs9465871 |
| HLI | rs9465871 |
| Exac | rs9465871 |
| Gnomad | rs9465871 |
| Varsome | rs9465871 |
| LitVar | rs9465871 |
| Map | rs9465871 |
| PheGenI | rs9465871 |
| Biobank | rs9465871 |
| 1000 genomes | rs9465871 |
| hgdp | rs9465871 |
| ensembl | rs9465871 |
| geneview | rs9465871 |
| scholar | rs9465871 |
| rs9465871 | |
| pharmgkb | rs9465871 |
| gwascentral | rs9465871 |
| openSNP | rs9465871 |
| 23andMe | rs9465871 |
| SNPshot | rs9465871 |
| SNPdbe | rs9465871 |
| MSV3d | rs9465871 |
| GWAS Ctlg | rs9465871 |
| GMAF | 0.3627 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs9465871 has been reported in a large study to be associated with type-2 diabetes.
The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with heterozygotes is 1.18 (CI 1.04-1.34), and for homozygotes, 2.17 (CI 1.6-2.95). [PMID 17554300
]
[PMID 18633108] When combined, each additional risk allele from rs9465871, rs10811661, rs4402960, and rs13266634 increased the risk for type 2 diabetes by 1.24-fold (P = 2.85 x 10(-7)) or for combined IFG/type 2 diabetes by 1.21-fold (P = 6.31 x 10(-11)) in Chinese Hans
| GWAS | |
|---|---|
| SNP | rs9465871 |
| PubMedID | [PMID 17554300]
|
| Condition | Type 2 diabetes |
| Gene | CDKAL1 |
| Risk Allele | C |
| pValue | 3.00E-007 |
| OR | 1.18 |
| 95% CI | 1.04-1.34 |
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 19862325] PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
[PMID 19931040] Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.
[PMID 20847106] Association of a cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) polymorphism with elevated hemoglobin A(1)(c) levels and the prevalence of metabolic syndrome in Japanese men: interaction with dietary energy intake.
[PMID 21368910] Heterogeneity of genetic associations of CDKAL1 and HHEX with susceptibility of type 2 diabetes mellitus by gender.
