rs9858542
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 1.3 | 1.8x risk of Crohn's disease |
| (A;G) | 1.2 | 1.1x risk Crohn's Disease |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 49664550 |
| Gene | BSN |
| is a | snp |
| is | mentioned by |
| dbSNP | rs9858542 |
| dbSNP (classic) | rs9858542 |
| ClinGen | rs9858542 |
| ebi | rs9858542 |
| HLI | rs9858542 |
| Exac | rs9858542 |
| Gnomad | rs9858542 |
| Varsome | rs9858542 |
| LitVar | rs9858542 |
| Map | rs9858542 |
| PheGenI | rs9858542 |
| Biobank | rs9858542 |
| 1000 genomes | rs9858542 |
| hgdp | rs9858542 |
| ensembl | rs9858542 |
| geneview | rs9858542 |
| scholar | rs9858542 |
| rs9858542 | |
| pharmgkb | rs9858542 |
| gwascentral | rs9858542 |
| openSNP | rs9858542 |
| 23andMe | rs9858542 |
| SNPshot | rs9858542 |
| SNPdbe | rs9858542 |
| MSV3d | rs9858542 |
| GWAS Ctlg | rs9858542 |
| GMAF | 0.2199 |
| Max Magnitude | 1.3 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
rs9858542 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.09 (CI 0.96-1.24), and for homozygotes, 1.84 (CI 1.49-2.26). [PMID 17554300
]
| GWAS | |
|---|---|
| SNP | rs9858542 |
| PubMedID | [PMID 17554261]
|
| Condition | Crohn's disease |
| Gene | MST1 |
| Risk Allele | |
| pValue | 5.00E-008 |
| OR | 1.17 |
| 95% CI | 1.14-1.31 |
[PMID 20024904] Variants at the 3p21 locus influence susceptibility and phenotype both in adults and early-onset patients with inflammatory bowel disease
| GWAS snp | |
|---|---|
| PMID | [PMID 19915572]
|
| Trait | Ulcerative colitis |
| Title | Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region |
| Risk Allele | |
| P-val | 7E-9 |
| Odds Ratio | NR NR |
[PMID 19657358] Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 19140132] Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
[PMID 20369022] Candidate causal regulatory effects by integration of expression QTLs with complex trait genetic associations.
