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TYMS

From SNPedia
is agene
is mentioned by
Full namethymidylate synthetase
EntrezGene7298
PheGenI7298
VariationViewer7298
ClinVarTYMS
GeneCardsTYMS
dbSNP7298
DiseasesTYMS
SADR7298
HugeNav7298
wikipediaTYMS
googleTYMS
gopubmedTYMS
EVSTYMS
HEFalMpTYMS
MyGene2TYMS
23andMeTYMS
UniProtP04818
EnsemblENSG00000176890
OMIM188350
# SNPs16
 Max MagnitudeChromosome positionSummary
rs10017610662,103
rs1059394672,792
rs1512643600673,444
rs16430673,444
rs169483050668,465
rs26121000672,363
rs2790673,086
rs28471490666,371
rs28535330658,064
rs2853539659,829
rs2853542657,685
rs34489327673,451
rs34743033657,646
rs45445694657,646
rs5023960659,236
rs6995170673,016


The TYMS gene encodes the enzyme thymidylate synthase, which is the primary target of 5-fluorouracil as used in chemotherapeutic treatment of various cancers. Variations in the the TYMS gene can influence risk for toxicity, including:

  • rs16430, in the 3' UTR of the gene; a 6bp insertion/deletion polymorphism
  • rs45445694, a 28bp VNTR
  • rs34743033, a G>C SNP in 2nd repeat of 3R allele