Talk:Rs1736557(A;A)

Possible connection (disputed) to trimethylaminuria This missense homozgous genotype has been reported to be associated with trimethylaminuria, yet other reports indicate it may be a benign polymorphism. Feel free to share your findings/beliefs with SNPedia if you have this genotype.

Trimethylaminuria (TMAU), also known as fish odor syndrome or fish malodor syndrome,[1] is a rare metabolic disorder that causes a defect in the normal production of the enzyme flavin containing monooxygenase 3 (FMO3).[2][3] When FMO3 is not working correctly or if not enough enzyme is produced, the body loses the ability to properly convert trimethylamine (TMA) from precursor compounds in food digestion into trimethylamine oxide (TMAO) through a process called N-oxygenation. Trimethylamine then builds up and is released in the person's sweat, urine, and breath, giving off a strong fishy odor or strong body odor.

I am age a 52 male with a reported A;A (23andme). I would like to report I have never had an issue with fishy or strong body odor, and in fact feel I am normal vs non-relatives in this regard.

Thank you. I've updated the text. --- cariaso 06:33, 26 June 2014 (UTC)