Talk:Rs449647(A;A)
From SNPedia
Is a lower or a higher ApoE level a risk? Gladstone Institutes. "Scientists find increased ApoE protein levels may promote Alzheimer's disease." ScienceDaily. ScienceDaily, 3 April 2012. www.sciencedaily.com/releases/2012/04/120403172156.htm
Not an answer, but at least some specific data points to help focus the discussion
- http://www.jneurosci.org/content/28/45/11445.full "Recent data suggest that inheritance of ε4 may lead to reduced apoE protein levels in the CNS. We therefore examined apoE protein levels in the brains, CSF and plasma of ε2/2, ε3/3, and ε4/4 targeted replacement mice. These apoE mice showed a genotype-dependent decrease in apoE levels; ε2/2 >ε3/3 >ε4/4. Next, we sought to examine the relative contributions of apoE4 and apoE3 in the ε3/4 mouse brains. ApoE4 represented 30–40% of the total apoE. Moreover, the a" this suggests lower levels are more like ε4/4, so lower levels = bad
- https://www.ncbi.nlm.nih.gov/pubmed/9058415 "A significant increase in the level of plasma apoE was observed in non-fasted late-onset AD patients (with a mean level of 3.26 +/- 0.08 microgram apoE/mg total protein for n = 84 patients) when compared with the plasma apoE levels of control individuals (mean of 2.32 +/- 0.10 microgram apoE/mg total protein, n = 51 patients; P < 0.001). A similar increase was found for non-fasted early-onset AD patients (mean of 3.69 +/- 0.17 microgram apoE/mg total protein, n = 20) when compared with the plasma apoE levels of control individuals (P < 0.001)" suggesting higher levels = bad
--- cariaso 10:40, 28 April 2016 (UTC)
