Talk:Rs8176719
https://www.23andme.com/you/community/thread/121/ has more information on this topic.
SNPedia inconsistent with 23andMe and within itself.[edit]
- This 1 is the opposite:
- However, an individual will only be blood group type O if they are carry two copies of (are homozygous) for this deletion, in other words, if their genotype is rs8176719(-;-). If they carry one copy, they could be blood type A, or blood type B (but not O).
- Of this 2:
- rs8176719(-;-) likely to be of blood type A, B or AB, but not O
- rs8176719(-;G) likely to be of blood type A or B, but not O
- rs8176719(G;G) likely to be of blood type O
Make no mistake. An O blood group will have the rs8176719(-;-) allele. I know that for a fact. John Lloyd Scharf 02:40, 16 November 2011 (UTC)
- This warrants investigation, and does appear to be inconsistent. I'll dive into it more and report back within 24 hours. Lennon
- Corrected phenotypic consequences - which were indeed incorrect - and clarified the text a bit. Thanks for calling attention to this. Lennon
If you are an O/O negative and receive blood from a O/A or O/B DONOR, it seems to be cause problems, according to: "Nondeletional ABO*O alleles frequently cause blood donor typing problems" (Wagner FF, Blasczyk R, Seltsam A., 2005). [PMID 16078922] The fact that the A/O or B/O can or :rs8176719(-;G) blood is typed as O does not mean it is a match to O- or O+. Giving a person rs8176719(-;-) blood the rs8176719(-;G) can lead to a recipient reaction either immediately or in the development of antibodies that will be lethal the next time they receive blood. John Lloyd Scharf 01:58, 17 November 2011 (UTC)
ALSO SEE: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076366/ John Lloyd Scharf 02:10, 17 November 2011 (UTC)
- I believe your statement above, but do not understand if it indicates a further problem in SNPedia. Are you indicating a problem with gs128? Or perhaps its a distinct warning about the compatibility of blood transfusions? The entire ABO blood group system is an artifact of a pre-genetics age. I'd love to see it phased out, and a more contemporary one introduced, which is better able to identify transfusion compatibility. --- cariaso 02:37, 17 November 2011 (UTC)
But, ALSO SEE: http://www.ncbi.nlm.nih.gov/pubmed/18482182
Earlier studies seem to have relied on samples for which ambiguous results had already been obtained. In some cases, further investigation resulted in the discovery of alleles that are not, in fact, non-deletional O alleles -- such as Bw. The study I have referenced took a different approach. The authors began with samples that had already been tested unambiguously as O. The samples were then genotyped, and those found to be O2 (non-deletional) were subjected to further testing. The authors concluded that "Other than lower plasma anti-A titers, GTA activity was not found in these O2 samples. Neither automated blood grouping discrepancies nor clinical problems related to transfusing these O2 units were observed."
At present it does not appear to be justified to presume that "non-deletional O alleles" are really not O alleles at all; thus the current wording of this article seems appropriate.
