Topiramate

Topiramate, brand name Topamax, is an anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss. The drug had previously been used off-label for this purpose. Now available generically, topiramate has been at least occasionally used in the treatment of many conditions, including alcoholism, methamphetamine addiction, cocaine addiction, obesity, migraine, post-traumatic stress disorder, essential tremor, bulimia nervosa, obsessive compulsive disorder, smoking cessation, idiopathic intracranial hypertension and cluster headaches.Wikipedia

Topiramate has a long list of potential side effects, and like several other antiepileptic drugs, it may increase the risk of congenital malformations. This might be particularly important for women who take topiramate to prevent migraine attacks. In March 2011 the FDA notified healthcare professionals and patients of an increased risk of development of cleft lip and/or cleft palate (oral clefts) in infants born to women treated with Topamax (topiramate) during pregnancy and placed it in Pregnancy Category D.Wikipedia

In the treatment of alcoholism, a (very) preliminary report found that [topiramate] was most effective in reducing heavy drinking episodes for rs2832407(C;C) patients.