SNPs involved in a genetic propensity for vitamin D insufficiency, based on an article published online in The Lancet on June 10, 2010, include:
Individuals with three confirmed risk variants were at increased risk of having 25-hydroxyvitamin D concentrations lower than 75 nmol/L (OR 2·47, 95% CI 2·20—2·78, p=2·3×10?48) or lower than 50 nmol/L (1·92, 1·70—2·16, p=1·0×10?26) compared with those in the lowest quartile.10.1016/S0140-6736(10)60588-0
A variant in the CYP2R1 gene is reported to have a greater effect than previously reported SNPs; see rs117913124.
