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From SNPedia

Ziagen is the trade name of an antiviral drug used primarily to treat HIV+ and AIDS patients. The generic name is abacavir; it is also prescribed in the combination formulations Trizivir (abacavir, zidovudine and lamivudine) and Kivexa/Epzicom. More information about abacavir is available at Wikipedia.

The primary contraindication is a hypersensitive reaction that is likely to be genetic and can be severe. SNPs associated with the hypersensitive reaction are:

  • rs2395029, acting as a proxy for the HLA-B*5701 allele