Have questions? Visit https://www.reddit.com/r/SNPedia

Graves' disease

From SNPedia

Wikipedia (as edited July 22, 2017) re Graves' disease, a form of autoimmune thyroid disease (AITD) in which the body produces antibodies to the receptor for thyroid-stimulating hormone. Antibodies to thyroglobulin and to the thyroid hormones T3 and T4 may also be produced. Graves' disease occurs in about 0.5% of people. It occurs about 7.5 times more often in women than men. Often it starts between the ages of 40 and 60. It is the most common cause of hyperthyroidism (overactive thyroid) and general thyroid enlargement in developed countries.

SNPs reported to be associated with risk for Graves' disease include:


A 2007 article titled "The Link between Graves’ Disease and Hashimoto’s Thyroiditis: A Role for Regulatory T Cells" [1] reported that "Hyperthyroidism in Graves’ disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto’s thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies. In some Graves’ patients, thyroiditis becomes sufficiently extensive to cure the hyperthyroidism with resultant hypothyroidism."

See SNPedia's Autoimmune thyroiditis page for more info and citations.