CCR2
From SNPedia
| is a | gene |
| is | mentioned by |
| EntrezGene | 1231 |
| PheGenI | 1231 |
| VariationViewer | 1231 |
| ClinVar | CCR2 |
| GeneCards | CCR2 |
| dbSNP | 1231 |
| Diseases | CCR2 |
| SADR | 1231 |
| HugeNav | 1231 |
| wikipedia | CCR2 |
| CCR2 | |
| gopubmed | CCR2 |
| EVS | CCR2 |
| HEFalMp | CCR2 |
| MyGene2 | CCR2 |
| 23andMe | CCR2 |
| # SNPs | 2 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1034382 | 0 | 46,361,910 | |
| rs1799864 | 0 | 46,357,717 |
CCR2 is a chemokine receptor gene; some of these receptors, most notably CCR5, are targets for HIV infection and thus the potential of the development of AIDS.
Compared with individuals without CCR5-Delta32 (a variation in another gene) or the CCR2 rs1799864(A) allele, individuals with one or two copies of rs1799864(A) had a 58% lower risk of developing AIDS during the first 4 years after testing positive for HIV, a 19% lower risk during the subsequent 4 years, and no significant protection thereafter. [PMID 12556692] No protective effect (ie no benefit) was seen for this SNP once AIDS had developed. [PMID 11694103]
