rs1799864
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | ||
| (A;G) | ||
| (G;G) | 0 | common in clinvar |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 46357717 |
| Gene | CCR2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1799864 |
| dbSNP (classic) | rs1799864 |
| ClinGen | rs1799864 |
| ebi | rs1799864 |
| HLI | rs1799864 |
| Exac | rs1799864 |
| Gnomad | rs1799864 |
| Varsome | rs1799864 |
| LitVar | rs1799864 |
| Map | rs1799864 |
| PheGenI | rs1799864 |
| Biobank | rs1799864 |
| 1000 genomes | rs1799864 |
| hgdp | rs1799864 |
| ensembl | rs1799864 |
| geneview | rs1799864 |
| scholar | rs1799864 |
| rs1799864 | |
| pharmgkb | rs1799864 |
| gwascentral | rs1799864 |
| openSNP | rs1799864 |
| 23andMe | rs1799864 |
| SNPshot | rs1799864 |
| SNPdbe | rs1799864 |
| MSV3d | rs1799864 |
| GWAS Ctlg | rs1799864 |
| GMAF | 0.169 |
| Max Magnitude | 0 |
Compared with individuals without CCR5-Delta32 (a variation in another gene) or rs1799864(A), individuals with one or two copies of rs1799864(A) had a 58% lower risk of developing AIDS during the first 4 years after testing positive for HIV, a 19% lower risk during the subsequent 4 years, and no significant protection thereafter. [PMID 12556692] No protective effect (ie no benefit) was seen for this SNP once AIDS had developed. [PMID 11694103]
[PMID 19263529
] rs1799864(G), rs3025058(A) and rs662 were associated with increased risk, and rs1800775(A) with reduced risk of recurrent venous thromboembolism
[PMID 19506371] Single Nucleotide Polymorphisms in Monocyte Chemoattractant Protein-1 and Its Receptor Act Synergistically to Increase the Risk of Carotid Atherosclerosis
[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine
[PMID 20153665] Genetic variation at the CCR5/CCR2 gene cluster and risk of psoriasis and psoriatic arthritis
| ? | (A;A) (A;G) (G;G) | |
|---|---|---|
|
| ||
[PMID 22733495] Association of inflammatory chemokine gene CCL2I/D with bladder cancer risk in North Indian population
| ClinVar | |
|---|---|
| Risk | Rs1799864(A;A) |
| Alt | Rs1799864(A;A) |
| Reference | Rs1799864(G;G) |
| Significance | Other |
| Disease | Human immunodeficiency virus type 1 |
| Variation | info |
| Gene | CCR2 |
| CLNDBN | Human immunodeficiency virus type 1, susceptibility to |
| Reversed | 0 |
| HGVS | NC_000003.11:g.46399208G>A |
| CLNSRC | OMIM Allelic Variant UniProtKB (protein) |
| CLNACC | RCV000008756.2, |
[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.
[PMID 17079285] Genetic protection against hepatitis B virus conferred by CCR5Delta32: Evidence that CCR5 contributes to viral persistence.
[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
[PMID 17672867] Polymorphisms in chemokine receptor genes and susceptibility to Kawasaki disease.
[PMID 18172114] Comprehensive analysis of the candidate genes CCL2, CCR2, and TLR4 in age-related macular degeneration.
[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
[PMID 18805939] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.
[PMID 18936436] Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19073967] Shared and distinct genetic variants in type 1 diabetes and celiac disease.
[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.
[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.
[PMID 20031567] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.
[PMID 20041166] Common genetic variation and the control of HIV-1 in humans.
[PMID 20552027] Host and viral genetic correlates of clinical definitions of HIV-1 disease progression.
[PMID 21091093] Polymorphisms in chemokine and receptor genes and gastric cancer risk and survival in a high risk Polish population.
[PMID 23427179] Relationships of Single Nucleotide Polymorphisms of Monocyte Chemoattractant Protein 1 and Chemokine Receptor 2 With Susceptibility and Clinicopathologic Characteristics of Neoplasia of Uterine Cervix in Taiwan Women
[PMID 23632061] CCR2 and CCR5 genes polymorphisms in benign prostatic hyperplasia and prostate cancer
[PMID 24083412] Functional Genetic Polymorphisms of Monocyte Chemoattractant Protein 1 and C-C Chemokine Receptor Type 2 in Ischemic Stroke
[PMID 25760842] [Association of CCR2 gene rs1799864 polymorphism with hemophagocytic lymphohistiocytosis in children]
