rs1800775

Orientation

plus

Stabilized

plus

Make rs1800775(A;A)

Make rs1800775(A;C)

Make rs1800775(C;C)

Reference

GRCh38 38.1/141

Chromosome

16

Position

56961324

Gene

CETP

is a	snp
is	mentioned by
dbSNP	rs1800775
dbSNP (classic)	rs1800775
ClinGen	rs1800775
ebi	rs1800775
HLI	rs1800775
Exac	rs1800775
Gnomad	rs1800775
Varsome	rs1800775
LitVar	rs1800775
Map	rs1800775
PheGenI	rs1800775
Biobank	rs1800775
1000 genomes	rs1800775
hgdp	rs1800775
ensembl	rs1800775
geneview	rs1800775
scholar	rs1800775
google	rs1800775
pharmgkb	rs1800775
gwascentral	rs1800775
openSNP	rs1800775
23andMe	rs1800775
SNPshot	rs1800775
SNPdbe	rs1800775
MSV3d	rs1800775
GWAS Ctlg	rs1800775

GMAF

0.4844

Max Magnitude

0

?	(A;A) (A;C) (C;C)	28

[PMID 19263529] rs1799864(G), rs3025058(A) and rs662 were associated with increased risk, and rs1800775(A) with reduced risk of recurrent venous thromboembolism

Rs1800775
PubMed	[PMID 17463246]
Affy Probeset	SNP_A-2182111
Affy Orientation	same
On GW 5.0	0
Alleles A/B	A/C
Ancestral	A
Population	NEU
Allele	C
Case Freq.
Control Freq.	0.44
Odds Ratio Het
Odds Ratio Hom
Odds Ratio All	-
Disease	Elevated Apolipoprotein A1 (E-APOA1)

GWAS snp
PMID	[PMID 18193044]
Trait	HDL cholesterol
Title	Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
Risk Allele	C
P-val	1E-73
Odds Ratio	0.18 [0.16-0.20]% SD lower

[PMID 19435741] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people

OMIM	118470
Desc	CHOLESTERYL ESTER TRANSFER PROTEIN, PLASMA; CETP
Variant
Related	also

OMIM	612797
Desc	HIGH DENSITY LIPOPROTEIN CHOLESTEROL LEVEL QUANTITATIVE TRAIT LOCUS
Variant
Related	also

GWAS snp
PMID	[PMID 20031564]
Trait	HDL cholesterol
Title	Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction: Genomewide Analysis Among 18 245 Initially Healthy Women From the Women's Genome Health Study
Risk Allele	A
P-val	4E-93
Odds Ratio	3.09 mg/dL increase

[PMID 19773416] A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women

[PMID 21185205] The relationship of ACE and CETP gene polymorphisms with cardiovascular disease in a cohort of Asian Indian patients with and those without type 2 diabetes

[PMID 12434007] SNP genotyping on a genome-wide amplified DOP-PCR template.

[PMID 12475937] Association testing by DNA pooling: an effective initial screen.

[PMID 17903299] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.

[PMID 18513389] New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.

[PMID 18549840] Cholesterol ester transfer protein, interleukin-8, peroxisome proliferator activator receptor alpha, and Toll-like receptor 4 genetic variations and risk of incident nonfatal myocardial infarction and ischemic stroke.

[PMID 18637884] Cholesteryl ester transfer protein (CETP) genetic variation and early onset of non-fatal myocardial infarction.

[PMID 19041386] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19185284] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

[PMID 19197348] Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.

[PMID 19951432] Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

[PMID 20018036] Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.

[PMID 20205905] Association of repeatedly measured intermediate risk factors for complex diseases with high dimensional SNP data.

[PMID 20370913] Genome-wide association analysis of total cholesterol and high-density lipoprotein cholesterol levels using the Framingham heart study data.

[PMID 23351584] Common variation in cholesteryl ester transfer protein: relationship of first major adverse cardiovascular events with the apolipoprotein B/apolipoprotein A-I ratio and the total cholesterol/high-density lipoprotein cholesterol ratio

[PMID 24283500] CETP gene polymorphisms and risk of coronary atherosclerosis in a Chinese population

[PMID 22715478] Genotypes associated with lipid metabolism contribute to differences in serum lipid profile of GH-deficient adults before and after GH replacement therapy.

[PMID 23675527] The association of common SNPs and haplotypes in CETP gene with HDL cholesterol levels in Latvian population.

GWAS snp
PMID	[PMID 24023260]
Trait	Lipid traits
Title	Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
Risk Allele	A
P-val	3E-9
Odds Ratio	.04 [0.020-0.060] unit increase

GWAS snp
PMID	[PMID 24816252]
Trait	Blood metabolite levels
Title	An atlas of genetic influences on human blood metabolites.
Risk Allele	A
P-val	1E-11
Odds Ratio	.01 [0.0091-0.0169] unit increase

GWAS snp
PMID	[PMID 19936222]
Trait	Lipid metabolism phenotypes
Title	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Risk Allele
P-val	3E-93
Odds Ratio	3.10 [NR] unit increase

[PMID 28106113] Genetic risk variants for metabolic traits in Arab populations.

[PMID 29080057] Sex Differences in Blood HDL-c, the Total Cholesterol/HDL-c Ratio, and Palmitoleic Acid are Not Associated with Variants in Common Candidate Genes.