DDC
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | dopa decarboxylase (aromatic L-amino acid decarboxylase) |
| Other names | AADC |
| EntrezGene | 1644 |
| PheGenI | 1644 |
| VariationViewer | 1644 |
| ClinVar | DDC |
| GeneCards | DDC |
| dbSNP | 1644 |
| Diseases | DDC |
| SADR | 1644 |
| HugeNav | 1644 |
| wikipedia | DDC |
| DDC | |
| gopubmed | DDC |
| EVS | DDC |
| HEFalMp | DDC |
| MyGene2 | DDC |
| 23andMe | DDC |
| UniProt | P20711 |
| Ensembl | ENSG00000132437 |
| OMIM | 107930 |
| # SNPs | 31 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1085307991 | 0 | 50,544,015 | |
| rs11575461 | 0 | 50,479,485 | |
| rs11761683 | 1 | 50,475,181 | |
| rs11974297 | 1 | 50,550,562 | |
| rs12718541 | 1 | 50,482,446 | |
| rs137853207 | 0 | 50,539,926 | |
| rs137853208 | 0 | 50,504,025 | |
| rs137853209 | 0 | 50,495,369 | |
| rs137853210 | 0 | 50,529,339 | |
| rs137853211 | 0 | 50,539,958 | |
| rs137853212 | 0 | 50,499,201 | |
| rs1451371 | 0 | 50,485,353 | |
| rs1451375 | 0 | 50,555,014 | |
| rs1470750 | 0 | 50,508,950 | |
| rs201951824 | 0 | 50,476,625 | |
| rs2044859 | 1 | 50,544,864 | |
| rs2060762 | 0 | 50,461,686 | |
| rs2242041 | 0 | 50,461,751 | |
| rs2329340 | 1 | 50,552,531 | |
| rs3735273 | 0 | 50,529,166 | |
| rs3757472 | 0 | 50,470,285 | |
| rs3779084 | 0 | 50,501,037 | |
| rs3837091 | 0 | 50,561,043 | |
| rs6264 | 0 | 50,544,037 | |
| rs6592961 | 0 | 50,505,192 | |
| rs771317809 | 0 | 50,470,140 | |
| rs7809234 | 0 | 50,542,681 | |
| rs7809758 | 0 | 50,505,635 | |
| rs880028 | 0 | 50,502,438 | |
| rs921451 | 0 | 50,555,587 | |
| rs998850 | 0 | 50,539,690 |
catalyzes several decarboxylation reactions:
- L-DOPA to dopamine - a neurotransmitter
- 5-HTP to serotonin - also a neurotransmitter
- tryptophan to tryptamine
per OMIM, Ma et al. (2005) [PMID 15879433] found two different DDC haplotypes associated with nicotine dependence in African Americans and European Americans (with measures of smoking quantity [SQ], heaviness of smoking index [HSI], and the Fagerstrom test for ND [FTND])
