FLG
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | filaggrin |
| EntrezGene | 2312 |
| PheGenI | 2312 |
| VariationViewer | 2312 |
| ClinVar | FLG |
| GeneCards | FLG |
| dbSNP | 2312 |
| Diseases | FLG |
| SADR | 2312 |
| HugeNav | 2312 |
| wikipedia | FLG |
| FLG | |
| gopubmed | FLG |
| EVS | FLG |
| HEFalMp | FLG |
| MyGene2 | FLG |
| 23andMe | FLG |
| UniProt | P20930 |
| Ensembl | ENSG00000143631 |
| OMIM | 135940 |
| # SNPs | 57 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1057517973 | 0 | 152,310,881 | |
| rs1057518148 | 0 | 152,309,656 | |
| rs1057518212 | 0 | 152,303,358 | |
| rs1060499587 | 4 | 152,313,983 | |
| rs1064793675 | 0 | 152,311,049 | |
| rs1064795983 | 0 | 152,304,695 | |
| rs1064796105 | 0 | 152,305,164 | |
| rs1064796274 | 0 | 152,311,980 | |
| rs114733570 | 0 | 152,315,363 | |
| rs115746363 | 0 | 152,312,410 | |
| rs121909626 | 4 | 152,307,225 | |
| rs138726443 | 4 | 152,307,547 | |
| rs140980397 | 0 | 152,308,956 | |
| rs141784184 | 4 | 152,309,169 | |
| rs142991475 | 0 | 152,313,823 | |
| rs144419479 | 0 | 152,311,957 | |
| rs145119819 | 0 | 152,313,060 | |
| rs147145234 | 0 | 152,308,647 | |
| rs148606936 | 0 | 152,303,434 | |
| rs149105551 | 0 | 152,309,494 | |
| rs149484917 | 0 | 152,304,939 | |
| rs150597413 | 4 | 152,305,146 | |
| rs199885226 | 0 | 152,314,107 | |
| rs199895224 | 0 | 152,311,129 | |
| rs200002200 | 0 | 152,308,777 | |
| rs200519781 | 0 | 152,311,565 | |
| rs201356558 | 0 | 152,304,661 | |
| rs2485518 | 0 | 152,315,409 | |
| rs2786680 | 0 | 152,325,202 | |
| rs3120649 | 0 | 152,311,335 | |
| rs3126065 | 0 | 152,303,083 | |
| rs374588791 | 0 | 152,307,622 | |
| rs3814299 | 0 | 152,302,977 | |
| rs3814300 | 0 | 152,303,164 | |
| rs397507563 | 0 | 152,311,184 | |
| rs41370446 | 0 | 152,311,629 | |
| rs528722713 | 0 | 152,307,637 | |
| rs535289422 | 4 | 152,307,697 | |
| rs546871592 | 0 | 152,303,251 | |
| rs558269137 | 3.9 | 152,312,601 | |
| rs578184315 | 0 | 152,307,929 | |
| rs61816761 | 3.9 | 152,313,385 | |
| rs74129447 | 0 | 152,303,313 | |
| rs745516434 | 0 | 152,312,459 | |
| rs749083759 | 0 | 152,303,917 | |
| rs754812742 | 4 | 152,310,981 | |
| rs756998312 | 0 | 152,310,100 | |
| rs760831749 | 0 | 152,307,618 | |
| rs761212672 | 4 | 152,304,999 | |
| rs761877421 | 0 | 152,313,588 | |
| ... further results | |||
[PMID 16550169] - loss of function mutations in FLG, most commonly rs61816761 (R501X) or rs558269137 (2284del4), carried by ~9% of Europeans, strongly predisposed for atopic dermatitis "highly significant association with asthma occurring in the context of atopic dermatitis".
3x risk of peanut allergy http://www.cbc.ca/news/health/story/2011/03/11/peanut-allergy-gene.html
[PMID 18049447] - FLG mutations (R510X and 2284del4 genotyped) assoc. w/ nickel sensitivity and nickel sensitivity combined with jewelery intolerance, but not with other contact allergens, in a 1,502 strong subset of the KORA C study group.
considerably more information is available elsewhere. see wikipedia, a glut of PubMed-listed papers, and the FLG OMIM entry
