MC4R
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | melanocortin 4 receptor |
| EntrezGene | 4160 |
| PheGenI | 4160 |
| VariationViewer | 4160 |
| ClinVar | MC4R |
| GeneCards | MC4R |
| dbSNP | 4160 |
| Diseases | MC4R |
| SADR | 4160 |
| HugeNav | 4160 |
| wikipedia | MC4R |
| MC4R | |
| gopubmed | MC4R |
| EVS | MC4R |
| HEFalMp | MC4R |
| MyGene2 | MC4R |
| 23andMe | MC4R |
| UniProt | P32245 |
| Ensembl | ENSG00000166603 |
| OMIM | 155541 |
| # SNPs | 30 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs1057517991 | 0 | 60,371,539 | |
| rs10871777 | 2.1 | 60,184,530 | |
| rs11872992 | 0 | 60,373,354 | |
| rs121913557 | 0 | 60,372,202 | |
| rs121913558 | 0 | 60,372,178 | |
| rs121913559 | 0 | 60,372,045 | |
| rs121913560 | 0 | 60,371,842 | |
| rs121913561 | 0 | 60,371,529 | |
| rs121913562 | 0 | 60,371,538 | |
| rs121913563 | 0 | 60,371,827 | |
| rs121913564 | 0 | 60,371,403 | |
| rs121913565 | 0 | 60,372,061 | |
| rs121913566 | 0 | 60,372,165 | |
| rs121913567 | 0 | 60,371,694 | |
| rs121917829 | 0 | 60,371,489 | |
| rs12970134 | 0 | 60,217,517 | |
| rs13447324 | 5 | 60,372,245 | |
| rs13447325 | 0 | 60,372,240 | |
| rs13447331 | 0 | 60,371,970 | |
| rs17782313 | 2.5 | 60,183,864 | |
| rs193922685 | 0 | 60,371,812 | |
| rs193922687 | 0 | 60,371,513 | |
| rs2229616 | 2.1 | 60,372,043 | |
| rs52804924 | 0 | 60,371,454 | |
| rs52820871 | 0 | 60,371,599 | |
| rs747681609 | 0 | 60,371,856 | |
| rs751160202 | 0 | 60,372,144 | |
| rs772213710 | 0 | 60,372,069 | |
| rs79783591 | 0 | 60,371,544 | |
| rs8087522 | 0 | 60,373,245 |
Melanocortin 4 receptor is a protein that in humans is encoded by the MC4R gene. It encodes the MC4 protein, a G protein-coupled receptor that binds α-melanocyte stimulating hormone (α-MSH). In murine models MC4 receptors have been found to be involved in feeding behaviour, the regulation of metabolism, sexual behaviour, and male erectile function.Wikipedia
[PMID 27701398] Divergent effects of central melanocortin signalling on fat and sucrose preference in humans
| Fat preference | G252S 2 | |
| Fat preference | Y80X 1 | |
| Fat preference | R236C 1 | |
| Fat preference | I125K 4 | |
| Fat preference | C271Y 3 | rs121913562 |
| Fat preference | Y35X; D37V 2 | rs13447324; rs13447325 |
| Fat preference | I137T 1 | |
| Sucrose preference | I125K 2 | |
| Sucrose preference | E61K 2 | |
| Sucrose preference | C271Y 2 | rs121913562 |
| Sucrose preference | A144S 1 | |
| Sucrose preference | Y35X; D37V 2 | rs13447324; rs13447325 |
| Sucrose preference | F280AfsX12 1 | rs193922687 |
