rs10086908
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2 | 1.7x increased risk for prostate cancer |
| (C;T) | 2 | 1.7x increased risk for prostate cancer |
| (T;T) | 0 | normal risk |
| Reference | GRCh38 38.1/141 |
| Chromosome | 8 |
| Position | 126999692 |
| Gene | LOC105375751 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10086908 |
| dbSNP (classic) | rs10086908 |
| ClinGen | rs10086908 |
| ebi | rs10086908 |
| HLI | rs10086908 |
| Exac | rs10086908 |
| Gnomad | rs10086908 |
| Varsome | rs10086908 |
| LitVar | rs10086908 |
| Map | rs10086908 |
| PheGenI | rs10086908 |
| Biobank | rs10086908 |
| 1000 genomes | rs10086908 |
| hgdp | rs10086908 |
| ensembl | rs10086908 |
| geneview | rs10086908 |
| scholar | rs10086908 |
| rs10086908 | |
| pharmgkb | rs10086908 |
| gwascentral | rs10086908 |
| openSNP | rs10086908 |
| 23andMe | rs10086908 |
| SNPshot | rs10086908 |
| SNPdbe | rs10086908 |
| MSV3d | rs10086908 |
| GWAS Ctlg | rs10086908 |
| GMAF | 0.2769 |
| Max Magnitude | 2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs10086908 is a SNP in the 8q24 chromosomal region, which has been linked in several studies to prostate cancer.
In a study of 1,563 patients of European ancestry, rs10086908 was designated as the representative of a prostate cancer risk region termed "locus 3", with an odds ratio of 1.70 (CI: 1.39-2.07) for carriers of a risk genotype. Two other regions of chromosome 8q24 were also studied.[PMID 17925536]
[PMID 19549807
] Prostate Cancer Risk Associated Loci in African Americans
[PMID 19767752] Multiple loci on 8q24 associated with prostate cancer susceptibility
[PMID 21756274] Systematic confirmation study of reported prostate cancer risk-associated single nucleotide polymorphisms in Chinese men
[PMID 17978284] Confirmation study of prostate cancer risk variants at 8q24 in African Americans identifies a novel risk locus.
[PMID 18670647] Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer.
[PMID 23405784] [Susceptibility to prostate cancer in Han Chinese: single nucleotide polymorphism analysis of 1 667 cases]
[PMID 24779299] Study of genetic variants of 8q21 and 8q24 associated with prostate cancer in Jing-Jin residents in northern China
