rs10168266
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | normal risk of Sjogren's syndrome | |
| (C;T) | 1.44x risk of Sjogren's syndrome | |
| (T;T) | 1.44x risk of Sjogren's syndrome |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 191071078 |
| Gene | STAT4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10168266 |
| dbSNP (classic) | rs10168266 |
| ClinGen | rs10168266 |
| ebi | rs10168266 |
| HLI | rs10168266 |
| Exac | rs10168266 |
| Gnomad | rs10168266 |
| Varsome | rs10168266 |
| LitVar | rs10168266 |
| Map | rs10168266 |
| PheGenI | rs10168266 |
| Biobank | rs10168266 |
| 1000 genomes | rs10168266 |
| hgdp | rs10168266 |
| ensembl | rs10168266 |
| geneview | rs10168266 |
| scholar | rs10168266 |
| rs10168266 | |
| pharmgkb | rs10168266 |
| gwascentral | rs10168266 |
| openSNP | rs10168266 |
| 23andMe | rs10168266 |
| SNPshot | rs10168266 |
| SNPdbe | rs10168266 |
| MSV3d | rs10168266 |
| GWAS Ctlg | rs10168266 |
| GMAF | 0.2328 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 20176035] Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease
[PMID 18516230
] Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
[PMID 18579578] A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
[PMID 18803832] Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.
[PMID 19333953] High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.
[PMID 20169177] Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
[PMID 22569826] Abnormal Genetic and Epigenetic Changes in Signal Transducer and Activator of Transcription 4 in the Pathogenesis of Inflammatory Bowel Diseases.
[PMID 23755762] STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population
| GWAS snp | |
|---|---|
| PMID | [PMID 24097066] |
| Trait | Sjögren's syndrome |
| Title | A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sjögren's syndrome at 7q11.23. |
| Risk Allele | T |
| P-val | 2E-17 |
| Odds Ratio | 1.44 [1.32-1.57] |
[PMID 24741605] Insight into gene polymorphisms involved in toll-like receptor/interferon signalling pathways for systemic lupus erythematosus in South East Asia
[PMID 28852993] STAT4 Polymorphisms are Associated with Neuromyelitis Optica Spectrum Disorders.
[PMID 32973967] SNPs in the interleukin-12 signaling pathway are associated with breast cancer risk in Puerto Rican women.
