|(C;C)||0.1||normal cognitive ability|
|(T;T)||2||impaired cognitive ability|
g2b2mh blog In a population of healthy individuals, those that carry common variants (such as rs760761, rs1018381, rs2619522) located in the dysbindin (DTNBP1) gene, a risk factor for schizophrenia, show minor cognitive impairments such as decreased attentional capacity, worse performance on memory tasks, and alterations in schizotypal beliefs and experiences.
[PMID 19335929] Association of the DTNBP1 genotype with cognition and personality traits in healthy subjects.
[PMID 19497374] Genetic variation in schizophrenia-risk-gene dysbindin 1 modulates brain activation in anterior cingulate cortex and right temporal gyrus during language production in healthy individuals
[PMID 19077176] Variation in the dysbindin gene and normal cognitive function in three independent population samples
[PMID 19621369] The impact of dystrobrevin-binding protein 1 (DTNBP1) on neural correlates of episodic memory encoding and retrieval
[PMID 19650139] Impact of schizophrenia-risk gene dysbindin 1 on brain activation in bilateral middle frontal gyrus during a working memory task in healthy individuals
[PMID 20846375] The effects of a DTNBP1 gene variant on attention networks: an fMRI study
[PMID 21130223] Meta-Analysis of Genetic Variation in DTNBP1 and General Cognitive Ability
[PMID 12098102] Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia.
[PMID 12474144] Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families.
[PMID 14618545] The DTNBP1 (dysbindin) gene contributes to schizophrenia, depending on family history of the disease.
[PMID 15290652] A powerful strategy to account for multiple testing in the context of haplotype analysis.
[PMID 15362017] Association of the DTNBP1 locus with schizophrenia in a U.S. population.
[PMID 17033966] Analysis of high-resolution HapMap of DTNBP1 (Dysbindin) suggests no consistency between reported common variant associations and schizophrenia.
[PMID 17074466] DTNBP1 genotype influences cognitive decline in schizophrenia.
[PMID 17445278] Association between the DTNBP1 gene and intelligence: a case-control study in young patients with schizophrenia and related disorders and unaffected siblings.
[PMID 18663367] The dystrobrevin-binding protein 1 gene: features and networks.
[PMID 18715757] Genetic associations with schizophrenia: meta-analyses of 12 candidate genes.
[PMID 18797396] Association study of candidate variants from brain-derived neurotrophic factor and dystrobrevin-binding protein 1 with neuroticism, anxiety, and depression.
[PMID 18804346] Interaction between interleukin 3 and dystrobrevin-binding protein 1 in schizophrenia.
[PMID 19369910] The efficacies of clozapine and haloperidol in refractory schizophrenia are related to DTNBP1 variation.
[PMID 19862852] Association study of DTNBP1 with schizophrenia in a US sample.
[PMID 19911060] Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.
[PMID 22019876] The impact of a Dysbindin schizophrenia susceptibility variant on fiber tract integrity in healthy individuals: a TBSS-based diffusion tensor imaging study.
[PMID 22580710] The DTNBP1 (dysbindin-1) gene variant rs2619522 is associated with variation of hippocampal and prefrontal grey matter volumes in humans.
[PMID 22911901] Association of genetic variations in DTNBP1 with cognitive function in schizophrenia patients and healthy subjects.