rs10260404
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2 | 1.60x risk of developing ALS |
| (C;T) | 1.5 | 1.20x risk of developing ALS |
| (T;T) | 1 | Normal risk of developing ALS |
| Reference | GRCh38 38.1/141 |
| Chromosome | 7 |
| Position | 154513713 |
| Gene | DPP6 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10260404 |
| dbSNP (classic) | rs10260404 |
| ClinGen | rs10260404 |
| ebi | rs10260404 |
| HLI | rs10260404 |
| Exac | rs10260404 |
| Gnomad | rs10260404 |
| Varsome | rs10260404 |
| LitVar | rs10260404 |
| Map | rs10260404 |
| PheGenI | rs10260404 |
| Biobank | rs10260404 |
| 1000 genomes | rs10260404 |
| hgdp | rs10260404 |
| ensembl | rs10260404 |
| geneview | rs10260404 |
| scholar | rs10260404 |
| rs10260404 | |
| pharmgkb | rs10260404 |
| gwascentral | rs10260404 |
| openSNP | rs10260404 |
| 23andMe | rs10260404 |
| SNPshot | rs10260404 |
| SNPdbe | rs10260404 |
| MSV3d | rs10260404 |
| GWAS Ctlg | rs10260404 |
| GMAF | 0.2888 |
| Max Magnitude | 2 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
rs10260404, a SNP in the region of the DPP6 gene on chromosome 7, has been associated with the sporadic form of ALS (Lou Gehrig's disease) in a study of 1000+ European patients. The overall odds ratio for the risk allele rs10260404(C) is 1.30 (CI: 1.18-1.43, p=0.017). When broken down by genotype, the odds ratios for heterozygotes are 1.20 (CI: 1.06-1.41), and for rs10260404(C;C) homozygotes, 1.60 (CI: 1.32-1.92).[PMID 18084291]
A "C-C" haplotype for this SNP and that of it's neighbor rs10239794 is also highly (statistically; p=10e-9) associated with ALS. [PMID 18084291]
However, in an expanded study pooling 4 populations (Irish, Dutch, US, Polish) rs10260404 failed to reach Bonferroni significance. although it did remain significant in the (expanded) Irish-only population.[PMID 18987618
]
| GWAS | |
|---|---|
| SNP | rs10260404 |
| PubMedID | [PMID 18057069] |
| Condition | Amyotrophic lateral sclerosis |
| Gene | DPP6 |
| Risk Allele | |
| pValue | 3.00E-006 |
| OR | 1.37 |
| 95% CI | 1.20-1.56 |
[PMID 19193627] A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis.
[PMID 19525032] No association of DPP6 with amyotrophic lateral sclerosis in an Italian population.
[PMID 20137488] Association between DPP6 polymorphism and the risk of sporadic amyotrophic lateral sclerosis in Chinese patients.
[PMID 22795786] No association of five candidate genetic variants with amyotrophic lateral sclerosis in a Chinese population
