rs1042778
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (T;T) | 1.5 | Slightly lower oxytocin & empathy? Possibly higher 'callous-unemotional' trait frequency in children. |
| Make rs1042778(G;G) |
| Make rs1042778(G;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 3 |
| Position | 8752859 |
| Gene | OXTR |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1042778 |
| dbSNP (classic) | rs1042778 |
| ClinGen | rs1042778 |
| ebi | rs1042778 |
| HLI | rs1042778 |
| Exac | rs1042778 |
| Gnomad | rs1042778 |
| Varsome | rs1042778 |
| LitVar | rs1042778 |
| Map | rs1042778 |
| PheGenI | rs1042778 |
| Biobank | rs1042778 |
| 1000 genomes | rs1042778 |
| hgdp | rs1042778 |
| ensembl | rs1042778 |
| geneview | rs1042778 |
| scholar | rs1042778 |
| rs1042778 | |
| pharmgkb | rs1042778 |
| gwascentral | rs1042778 |
| openSNP | rs1042778 |
| 23andMe | rs1042778 |
| SNPshot | rs1042778 |
| SNPdbe | rs1042778 |
| MSV3d | rs1042778 |
| GWAS Ctlg | rs1042778 |
| GMAF | 0.3655 |
| Max Magnitude | 1.5 |
| ? | (G;G) (G;T) (T;T) | 28 |
|---|---|---|
|
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blog rs1042778, rs2268490 and rs237887 in OXTR influence prosociality
[PMID 24059750] Polymorphisms in the oxytocin receptor gene are associated with the development of psychopathy. A study of ~120 children, followed by a replication in ~100 children, concluded that the rs1042778(T;T) genotype was associated with high levels of callous-unemotional (CU) traits in both samples.
[PMID 22357335] The association between oxytocin receptor gene polymorphism (OXTR) and trait empathy
[PMID 22421562] Associations between oxytocin receptor gene (OXTR) polymorphisms and self-reported aggressive behavior and anger: Interactions with alcohol consumption
[PMID 12444087] Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.
[PMID 17668382
] Type 2 diabetes whole-genome association study in four populations: the DiaGen consortium.
[PMID 19461999] The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task.
[PMID 19943975] Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms.
[PMID 20585395] No association between oxytocin receptor (OXTR) gene polymorphisms and experimentally elicited social preferences.
[PMID 20587075] Genetic evidence of multiple loci in dystocia--difficult labour.
[PMID 21484202] Association of oxytocin receptor (OXTR) gene variants with multiple phenotype domains of autism spectrum disorder.
[PMID 22336563] Sensitive Parenting Is Associated with Plasma Oxytocin and Polymorphisms in the OXTR and CD38 Genes.
[PMID 22372486] The role of oxytocin and oxytocin receptor gene variants in childhood-onset aggression.
[PMID 23974948] Cumulative Risk on the Oxytocin Receptor Gene (OXTR) Underpins Empathic Communication Difficulties at the First Stages of Romantic Love
[PMID 24485285] Association between the oxytocin receptor (OXTR) gene and mesolimbic responses to rewards
[PMID 23325323] Parental oxytocin and early caregiving jointly shape children's oxytocin response and social reciprocity.
