rs10489629

Orientation

minus

Stabilized

minus

Geno	Mag	Summary
(A;A)		0.83x lower risk for spondylitis
(A;G)		0.83x lower risk for spondylitis
(G;G)		normal risk

Reference

GRCh38 38.1/141

Chromosome

1

Position

67222666

Gene

IL23R

is a	snp
is	mentioned by
dbSNP	rs10489629
dbSNP (classic)	rs10489629
ClinGen	rs10489629
ebi	rs10489629
HLI	rs10489629
Exac	rs10489629
Gnomad	rs10489629
Varsome	rs10489629
LitVar	rs10489629
Map	rs10489629
PheGenI	rs10489629
Biobank	rs10489629
1000 genomes	rs10489629
hgdp	rs10489629
ensembl	rs10489629
geneview	rs10489629
scholar	rs10489629
google	rs10489629
pharmgkb	rs10489629
gwascentral	rs10489629
openSNP	rs10489629
23andMe	rs10489629
SNPshot	rs10489629
SNPdbe	rs10489629
MSV3d	rs10489629
GWAS Ctlg	rs10489629

GMAF

0.4472

Max Magnitude

0

?	(A;A) (A;G) (G;G)	28

rs10489629 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.83 (p=0.00014).[PMID 17952073, PMID 18037607]

[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility

[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis

[PMID 22440928] Perianal Crohn's Disease: Predictive Factors and Genotype-Phenotype Correlations

[PMID 17068223] A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.

[PMID 17678723] Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.

[PMID 17786191] rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.

[PMID 18047539] Association between genetic variants in the IL-23R gene and early-onset Crohn's disease: results from a case-control and family-based study among Canadian children.

[PMID 18383363] Association of interleukin-23 receptor variants with ankylosing spondylitis.

[PMID 19175939] IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.

[PMID 19306001] No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.

[PMID 19522770] Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples.

[PMID 19757086] Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients.

[PMID 19918037] Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.

[PMID 20454450] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.

[PMID 21253733] Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.

[PMID 22718508] Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis.

[PMID 23053963] Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.

[PMID 28210080] IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis.

[PMID 27320770] Impact of the IL-17F, IL-23 and IL-23R on susceptibility and phenotype of systemic lupus erythematosus.