rs1057910(C;C)
From SNPedia
| CYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugs |
| Is a | genotype |
| of | rs1057910 |
| Gene | CYP2C9 |
| Chromosome | 10 |
| Position | 94,981,296 |
| Merged from | Rs17847042 |
| mentioned | by |
| Magnitude | 4 |
| Repute | Bad |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0.1 | normal; no effect on warfarin metabolism |
| (A;C) | 2.5 | CYP2C9*3 carrier; average 40% reduction in warfarin metabolism |
| (C;C) | 4 | CYP2C9*3 homozygote; average 80% reduction in warfarin metabolism; reduced metabolism of number of other drugs |
- 12x risk of severe cutaneous adverse reactions when taking antiepileptic drug phenytoin. [PMID 25096692]
- rs1057910(C;C) genotypes may clear drugs like celecoxib (trade name Celebrex) twice as slowly as rs1057910(A;A) genotypes; the rs1057910(A;C) genotypes are in-between clearance rates. Lower clearance rates will lead to higher internal concentrations of the drug. It is not clear whether this could lead to increased efficacy and/or increased side effects. [PMID 12893985]
- rs1057910(C;C) genotypes are poor metabolizers of tolbutamide, a sulfonylurea hypoglycemic drug used in the treatment of diabetes. [PMID 8873220]
- rs1057910(C;C) genotypes are poor metabolizers of phenytoin, a drug used to treat epilepsy, and therefore tend to need lower doses. [PMID 15805193
]
- rs1057910(C;C) genotypes are poor metabolizers of glipizide, a second generation sulfonylurea drug structurally similar to tolbutamide and also used as an oral hypoglycemic agent. [PMID 10208645]
- rs1057910(C;C) genotypes are poor metabolizers of warfarin, and therefore unusually sensitive. [PMID 9352571]
