rs1059611

plus

Geno	Mag	Summary
(T;T)	0	common in clinvar

Make rs1059611(C;C)

Make rs1059611(C;T)

Reference

GRCh38 38.1/141

Chromosome

8

Position

19967052

Gene

LPL

is a	snp
is	mentioned by
dbSNP	rs1059611
dbSNP (classic)	rs1059611
ClinGen	rs1059611
ebi	rs1059611
HLI	rs1059611
Exac	rs1059611
Gnomad	rs1059611
Varsome	rs1059611
LitVar	rs1059611
Map	rs1059611
PheGenI	rs1059611
Biobank	rs1059611
1000 genomes	rs1059611
hgdp	rs1059611
ensembl	rs1059611
geneview	rs1059611
scholar	rs1059611
google	rs1059611
pharmgkb	rs1059611
gwascentral	rs1059611
openSNP	rs1059611
23andMe	rs1059611
SNPshot	rs1059611
SNPdbe	rs1059611
MSV3d	rs1059611
GWAS Ctlg	rs1059611

GMAF

0.1235

Max Magnitude

0

?

(C;C) (C;T) (T;T)

28

[PMID 23735640] Lipoprotein lipase gene polymorphism rs1059611 functionally influences serum lipid concentrations

[PMID 19148283 ] Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

[PMID 21840003] Genetic variations at the lipoprotein lipase gene influence plasma lipid concentrations and interact with plasma n-6 polyunsaturated fatty acids to modulate lipid metabolism.

GWAS snp
PMID	[PMID 19936222 ]
Trait	Lipid metabolism phenotypes
Title	Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.
Risk Allele
P-val	2E-17
Odds Ratio	.07 [NR] unit decrease

ClinVar
Risk	rs1059611(C;C)
Alt	rs1059611(C;C)
Reference	Rs1059611(T;T)
Significance	Probable-non-pathogenic
Disease	Hyperlipoproteinemia
Variation	info
Gene	LPL
CLNDBN	Hyperlipoproteinemia, type I
Reversed	0
HGVS	NC_000008.10:g.19824563T>C
CLNSRC
CLNACC	RCV000277765.1,