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rs1061325

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(C;C) 2 Two copies of "farmer" CLTCL1 gene variant
(C;T) 2 One copy of "hunter-gather" CLTCL1 gene variant + one "farmer" variant
(T;T) 2 Two copies of "hunter-gatherer" CLTCL1 gene variant
ReferenceGRCh38.p7 38.3/151
Chromosome22
Position19196584
GeneCLTCL1
is asnp
is mentioned by
dbSNPrs1061325
dbSNP (classic)rs1061325
ClinGenrs1061325
ebirs1061325
HLIrs1061325
Exacrs1061325
Gnomadrs1061325
Varsomers1061325
LitVarrs1061325
Maprs1061325
PheGenIrs1061325
Biobankrs1061325
1000 genomesrs1061325
hgdprs1061325
ensemblrs1061325
geneviewrs1061325
scholarrs1061325
googlers1061325
pharmgkbrs1061325
gwascentralrs1061325
openSNPrs1061325
23andMers1061325
23andMe allrs1061325
SNPshotrs1061325
SNPdbers1061325
MSV3drs1061325
GWAS Ctlgrs1061325
Max Magnitude2
? (C;C) (C;T) (T;T) 28


Also known as M1316V or p.Met1316Val, rs1061325 represents a common variant in the clathrin heavy chain like 1 CLTCL1 gene on chromosome 22. The (T) allele is associated with the Met (M) codon, and the (C) with Val (V), as represented on the forward/plus strand.

A 2019 publication gathered a fair amount of attention in the popular press by speculating that the V1316 allele has a selective advantage in processing carbohydrate-rich diets (presumably including those with lots of sugar) of farmers compared to the M1316 allele found at somewhat higher frequencies in hunter-gatherers (who theoretically consume fewer carbs). The authors suggest that heterozygotes may have a selective advantage, with M1316 homozygotes presumably most prone to developing insulin resistance on modern diets.10.7554/eLife.41517