rs1062613
| Orientation | plus |
| Stabilized | plus |
| Make rs1062613(C;C) |
| Make rs1062613(C;T) |
| Make rs1062613(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 113975284 |
| Gene | HTR3A |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1062613 |
| dbSNP (classic) | rs1062613 |
| ClinGen | rs1062613 |
| ebi | rs1062613 |
| HLI | rs1062613 |
| Exac | rs1062613 |
| Gnomad | rs1062613 |
| Varsome | rs1062613 |
| LitVar | rs1062613 |
| Map | rs1062613 |
| PheGenI | rs1062613 |
| Biobank | rs1062613 |
| 1000 genomes | rs1062613 |
| hgdp | rs1062613 |
| ensembl | rs1062613 |
| geneview | rs1062613 |
| scholar | rs1062613 |
| rs1062613 | |
| pharmgkb | rs1062613 |
| gwascentral | rs1062613 |
| openSNP | rs1062613 |
| 23andMe | rs1062613 |
| SNPshot | rs1062613 |
| SNPdbe | rs1062613 |
| MSV3d | rs1062613 |
| GWAS Ctlg | rs1062613 |
| GMAF | 0.2337 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
Rs1062613 (C178T, Pro16Ser) is located within the 5' UTR of HTR3A and may effect HTR3A expression.
[PMID 11505217] reporter constructs containing the T allele showed increased HTR3A expression compared to the C allele
[PMID 14557147] CC and CT carriers associated with higher harm avoidance (p = 0.04) scores in 2 sample groups of Swedish women (366 in total), and non-conformity in 1 sample
[PMID 18359159] no significant association between treatment-resistant schizophrenia and Rs1062613, however, maintenance neuroleptic dose was significantly higher for TT carriers (p = 0.041)
[PMID 20168265] Influence of serotonin 3A and 3B receptor genes on clozapine treatment response in schizophrenia
[PMID 21420406
] The HTR3A polymorphism c. -42C>T is associated with amygdala responsiveness in patients with irritable bowel syndrome.
[PMID 22700043] Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia
[PMID 23290502] Serotonin transporter and receptor genes significantly impact nicotine dependence through genetic interactions in both European American and African American smokers
