rs10735810
| Merged into | rs2228570 |
| Orientation | minus |
| Stabilized | minus |
| Make rs10735810(C;C) |
| Make rs10735810(C;T) |
| Make rs10735810(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 47879112 |
| Gene | VDR |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10735810 |
| dbSNP (classic) | rs10735810 |
| ClinGen | rs10735810 |
| ebi | rs10735810 |
| HLI | rs10735810 |
| Exac | rs10735810 |
| Gnomad | rs10735810 |
| Varsome | rs10735810 |
| LitVar | rs10735810 |
| Map | rs10735810 |
| PheGenI | rs10735810 |
| Biobank | rs10735810 |
| 1000 genomes | rs10735810 |
| hgdp | rs10735810 |
| ensembl | rs10735810 |
| geneview | rs10735810 |
| scholar | rs10735810 |
| rs10735810 | |
| pharmgkb | rs10735810 |
| gwascentral | rs10735810 |
| openSNP | rs10735810 |
| 23andMe | rs10735810 |
| SNPshot | rs10735810 |
| SNPdbe | rs10735810 |
| MSV3d | rs10735810 |
| GWAS Ctlg | rs10735810 |
| Status | Merged into rs2228570 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 19178954] vitamin D metabolism
| Rs10735810 | |
|---|---|
| PubMed | [PMID 15459215] |
| Affy Probeset | SNP_A-8299185 |
| Affy Orientation | reverse |
| On GW 5.0 | 0 |
| Alleles A/B | C/T |
| Ancestral | |
| Population | US |
| Allele | G |
| Case Freq. | 0.78 |
| Control Freq. | 0.62 |
| Odds Ratio Het | 3.93 |
| Odds Ratio Hom | 6.56 |
| Odds Ratio All | |
| Disease | Osteonecrosis in acute lymphoblastic leukemia (ALL-ON) |
rs10735810 increases susceptibility to Idiopathic short stature 1.33 times for heterozygotes (AG) and 1.90 times for homozygotes (GG) [PMID 10770213]
rs10735810 increases susceptibility to Osteonecrosis in acute lymphoblastic leukemia 3.93 times for heterozygotes (AG) and 6.56 times for homozygotes (GG) [PMID 15459215]
[PMID 19105801
] rs2228570 aka rs10735810 allele (A) observed for breast cancer odds ratio (OR) of 1.26
[PMID 19383647] Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction
[PMID 18587672] Vitamin D receptor variants and breast cancer risk in the Polish population
[PMID 19499989] Vitamin D receptor polymorphisms in differentiated thyroid carcinoma
[PMID 19734102] Vitamin D receptor gene polymorphisms and susceptibility to type 1 diabetes in Crete, Greece
[PMID 19758194] Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis
[PMID 20363324] A systematic review of the association between common single nucleotide polymorphisms and 25-hydroxyvitamin D concentrations
[PMID 20473893] Vitamin D receptor rs2228570 polymorphism and invasive ovarian carcinoma risk: Pooled analysis in five studies within the Ovarian Cancer Association Consortium
[PMID 21837802] Confirmation of an association between single nucleotide polymorphisms in the VDR gene with respiratory syncytial virus related disease in South African Children
[PMID 22213340] 25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease
[PMID 22280097] Plasma Levels of Vitamin D in HIV Patients Initiating Antiretroviral Therapy Do Not Predict Immune Restoration Disease Associated with Mycobacterium tuberculosis.
[PMID 23173643] Vitamin D receptor gene polymorphism and cardiovascular risk variables in elderly Polish subjects
[PMID 23416105] Vitamin D status and gene transcription in immune cells
[PMID 24927719] Interrelation between genotypes of the vitamin D receptor gene and serum sex hormone concentrations in the Polish elderly population: the PolSenior study
[PMID 25376135] FokI vitamin D receptor gene polymorphism in association with multiple sclerosis risk and disability progression in Slovaks
[PMID 26093050] Vitamin D receptor gene polymorphisms in Alzheimer's disease patients
[PMID 26105695] FokI Polymorphism of the Vitamin D Receptor Gene Is Associated with Susceptibility to Gastric Cancer: A Case-Control Study
[PMID 26435642] Common VDR polymorphisms and idiopathic short stature in children from northern Greece
[PMID 27669215] Vitamin D-Related Gene Polymorphisms, Plasma 25-Hydroxy-Vitamin D, Cigarette Smoke and Non-Small Cell Lung Cancer (NSCLC) Risk.
