| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
1.5x risk of Crohn's disease
|
| (A;G)
|
1
|
1.2x risk of Crohn's disease
|
| (G;G)
|
0
|
normal
|
rs10761659 has been reported in a large study to be associated with Crohn's disease.
The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.23 (CI 1.05-1.45), and for homozygotes, 1.55 (CI 1.3-1.84). [PMID 17554300
]
[PMID 19174780] Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
| OMIM | 612255 |
| Desc | INFLAMMATORY BOWEL DISEASE 15; IBD15 |
| Variant | |
| Related | also |
| GWAS snp
|
| PMID
|
[PMID 21102463]
|
| Trait
|
|
| Title
|
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
|
| Risk Allele
|
G
|
| P-val
|
4E-22
|
| Odds Ratio
|
1.2300 [1.18-1.29]
|
[PMID 18224312] Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
[PMID 18438406] Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
[PMID 18533027] Worldwide population differentiation at disease-associated SNPs.
[PMID 18853133] Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.
[PMID 18936107] Positive association of genetic variants in the upstream region of NKX2-3 with Crohn's disease in Japanese patients.
[PMID 20846217] Association of linear growth impairment in pediatric Crohn's disease and a known height locus: a pilot study.
| GWAS snp
|
| PMID
|
[PMID 22936669]
|
| Trait
|
Crohn's disease
|
| Title
|
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
|
| Risk Allele
|
G
|
| P-val
|
5E-6
|
| Odds Ratio
|
1.28 [NR]
|
]
