rs1076560
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2 | influences working memory |
| (A;C) | 1.3x increased risk for alcoholism | |
| (C;C) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 113412966 |
| Gene | DRD2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1076560 |
| dbSNP (classic) | rs1076560 |
| ClinGen | rs1076560 |
| ebi | rs1076560 |
| HLI | rs1076560 |
| Exac | rs1076560 |
| Gnomad | rs1076560 |
| Varsome | rs1076560 |
| LitVar | rs1076560 |
| Map | rs1076560 |
| PheGenI | rs1076560 |
| Biobank | rs1076560 |
| 1000 genomes | rs1076560 |
| hgdp | rs1076560 |
| ensembl | rs1076560 |
| geneview | rs1076560 |
| scholar | rs1076560 |
| rs1076560 | |
| pharmgkb | rs1076560 |
| gwascentral | rs1076560 |
| openSNP | rs1076560 |
| 23andMe | rs1076560 |
| SNPshot | rs1076560 |
| SNPdbe | rs1076560 |
| MSV3d | rs1076560 |
| GWAS Ctlg | rs1076560 |
| GMAF | 0.2149 |
| Max Magnitude | 2 |
| ? | (A;A) (A;C) (C;C) | 28 |
|---|---|---|
|
| ||
rs1076560 is located in intron 6 of the dopamine receptor D2 gene.
In one study of Japanese males, rs1076560(A) alleles were 1.3 fold more associated with Alcoholism than the rs1076560(C) alleles. [PMID 17196743]
The DRD2 risk allele A was more prevalent in the alcoholic patients than in the healthy controls. These data identify rs1076560 as a potentially important variable in the development of alcoholism.
[PMID 19176830
] rs1076560 and the DAT 3'-VNTR variant influences memory
[PMID 19373123] Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
[PMID 19796663] Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients
[PMID 19940176] Functional Variation of the Dopamine D2 Receptor Gene Is Associated with Emotional Control as well as Brain Activity and Connectivity during Emotion Processing in Humans
[PMID 19512960] Genetic diagnostics of functional variants of the human dopamine D2 receptor gene
[PMID 20179754] Genetically Determined Measures of Striatal D2 Signaling Predict Prefrontal Activity during Working Memory Performance
[PMID 19393722] Genetic contributions to avoidance-based decisions: striatal D2 polymorphisms
[PMID 21087673] D2 receptor genotype and striatal dopamine signaling predict motor cortical activity and behavior in humans
[PMID 21150907] Intronic polymorphisms affecting alternative splicing of human dopamine D2 receptor are associated with cocaine abuse.
[PMID 22569179] Rs1076560, a functional variant of the dopamine D2 receptor gene, confers risk of schizophrenia in Han Chinese
[PMID 22745721] Cannabis-Dependence Risk Relates to Synergism between Neuroticism and Proenkephalin SNPs Associated with Amygdala Gene Expression: Case-Control Study
[PMID 18077373] Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory.
[PMID 19321766] Dopamine DRD2 polymorphism alters reversal learning and associated neural activity.
[PMID 20146828] Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study.
[PMID 20617039] Alcoholism and alternative splicing of candidate genes.
[PMID 21187413] DRD2/AKT1 interaction on D2 c-AMP independent signaling, attentional processing, and response to olanzapine treatment in schizophrenia.
[PMID 21645585] Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype.
[PMID 24322206] Contrasting changes in DRD1 and DRD2 splice variant expression in schizophrenia and affective disorders, and associations with SNPs in postmortem brain
[PMID 24359476] The Dopamine Receptor D2 (DRD2) SNP rs1076560 is Associated with Opioid Addiction
[PMID 24424781] DRD2 genotype predicts prefrontal activity during working memory after stimulation of D2 receptors with bromocriptine
[PMID 21976709] DRD2 genotype-based variation of default mode network activity and of its relationship with striatal DAT binding.
| ClinVar | |
|---|---|
| Risk | Rs1076560(A;A) |
| Alt | Rs1076560(A;A) |
| Reference | Rs1076560(C;C) |
| Significance | Drug-response |
| Disease | cocaine response - Toxicity/ADR |
| Variation | info |
| Gene | DRD2 |
| CLNDBN | cocaine response - Toxicity/ADR |
| Reversed | 0 |
| HGVS | NC_000011.9:g.113283688C>A |
| CLNSRC | |
| CLNACC | RCV000417152.1, |
