rs10821936
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 2.5 | Higher risk of childhood acute lymphoblastic leukemia |
| (C;T) | 2.1 | Higher risk of childhood acute lymphoblastic leukemia |
| (T;T) | normal |
| Reference | GRCh38 38.1/142 |
| Chromosome | 10 |
| Position | 61963818 |
| Gene | ARID5B |
| is a | snp |
| is | mentioned by |
| dbSNP | rs10821936 |
| dbSNP (classic) | rs10821936 |
| ClinGen | rs10821936 |
| ebi | rs10821936 |
| HLI | rs10821936 |
| Exac | rs10821936 |
| Gnomad | rs10821936 |
| Varsome | rs10821936 |
| LitVar | rs10821936 |
| Map | rs10821936 |
| PheGenI | rs10821936 |
| Biobank | rs10821936 |
| 1000 genomes | rs10821936 |
| hgdp | rs10821936 |
| ensembl | rs10821936 |
| geneview | rs10821936 |
| scholar | rs10821936 |
| rs10821936 | |
| pharmgkb | rs10821936 |
| gwascentral | rs10821936 |
| openSNP | rs10821936 |
| 23andMe | rs10821936 |
| SNPshot | rs10821936 |
| SNPdbe | rs10821936 |
| MSV3d | rs10821936 |
| GWAS Ctlg | rs10821936 |
| GMAF | 0.3108 |
| Max Magnitude | 2.5 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 19684603 ]
|
| Trait | Acute lymphoblastic leukemia (childhood) |
| Title | Germline genomic variants associated with childhood acute lymphoblastic leukemia |
| Risk Allele | C |
| P-val | 1E-15 |
| Odds Ratio | 1.91 [1.60-2.20] |
[PMID 22291082] ARID5B Genetic Polymorphisms Contribute to Racial Disparities in the Incidence and Treatment Outcome of Childhood Acute Lymphoblastic Leukemia
[PMID 22422485] Genetic variants modify susceptibility to leukemia in infants: A Children's Oncology Group report
[PMID 20460642] Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia.
[PMID 23608171] Association of three polymorphisms in ARID5B, IKZF1and CEBPE with the risk of childhood acute lymphoblastic leukemia in a Chinese population
| GWAS snp | |
|---|---|
| PMID | [PMID 23512250]
|
| Trait | Acute lymphoblastic leukemia (childhood) |
| Title | Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. |
| Risk Allele | C |
| P-val | 6E-46 |
| Odds Ratio | 1.86 [1.71-2.03] |
[PMID 23692655] ARID5B and IKZF1 variants, selected demographic factors, and childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group
[PMID 24564228] ARID5B polymorphism confers an increased risk to acquire specific MLL rearrangements in early childhood leukemia
[PMID 26177813] Replication analysis confirms the association of several variants with acute myeloid leukemia in Chinese population
[PMID 24707947] Genetic markers in a multi-ethnic sample for childhood acute lymphoblastic leukemia risk
[PMID 27279837] Analysis of possible genetic risk factors contributing to development of childhood acute lymphoblastic leukaemia in the Latvian population.
[PMID 29335448] Regional evaluation of childhood acute lymphoblastic leukemia genetic susceptibility loci among Japanese.
[PMID 31424309] ARID5B rs10821936 and rs10994982 gene polymorphisms and acute lymphoblastic leukemia: relation to disease susceptibility and outcome.
