rs11045879
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (T;T) | 0 | common in clinvar |
| Make rs11045879(C;C) |
| Make rs11045879(C;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 12 |
| Position | 21229685 |
| Gene | SLCO1B1 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11045879 |
| dbSNP (classic) | rs11045879 |
| ClinGen | rs11045879 |
| ebi | rs11045879 |
| HLI | rs11045879 |
| Exac | rs11045879 |
| Gnomad | rs11045879 |
| Varsome | rs11045879 |
| LitVar | rs11045879 |
| Map | rs11045879 |
| PheGenI | rs11045879 |
| Biobank | rs11045879 |
| 1000 genomes | rs11045879 |
| hgdp | rs11045879 |
| ensembl | rs11045879 |
| geneview | rs11045879 |
| scholar | rs11045879 |
| rs11045879 | |
| pharmgkb | rs11045879 |
| gwascentral | rs11045879 |
| openSNP | rs11045879 |
| 23andMe | rs11045879 |
| SNPshot | rs11045879 |
| SNPdbe | rs11045879 |
| MSV3d | rs11045879 |
| GWAS Ctlg | rs11045879 |
| GMAF | 0.2525 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 19901119
] Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects
[PMID 21387541] Polymorphisms of the SLCO1B1 gene predict methotrexate-related toxicity in childhood acute lymphoblastic leukemia
[PMID 19419973] Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.
| GWAS snp | |
|---|---|
| PMID | [PMID 23281178] |
| Trait | Metabolite levels |
| Title | A genome-wide assessment of variability in human serum metabolism. |
| Risk Allele | C |
| P-val | 5E-15 |
| Odds Ratio | NR NR |
[PMID 23222202] Polymorphisms in the methotrexate transport pathway: a new tool for MTX plasma level prediction in pediatric acute lymphoblastic leukemia.
[PMID 25098908] Influence of the folate pathway and transporter polymorphisms on methotrexate treatment outcome in osteosarcoma
| ClinVar | |
|---|---|
| Risk | rs11045879(C;C) |
| Alt | rs11045879(C;C) |
| Reference | Rs11045879(T;T) |
| Significance | Drug-response |
| Disease | Methotrexate response - Toxicity/ADR |
| Variation | info |
| Gene | SLCO1B1 |
| CLNDBN | methotrexate response - Toxicity/ADR |
| Reversed | 0 |
| HGVS | NC_000012.11:g.21382619T>C |
| CLNSRC | |
| CLNACC | RCV000417177.1, |
[PMID 31292326] Polymorphism in Organic Anion-Transporting Polypeptide Gene Related to Methotrexate Response in Rheumatoid Arthritis Treatment.
