rs11196205
| Orientation | plus |
| Stabilized | plus |
| Make rs11196205(C;C) |
| Make rs11196205(C;G) |
| Make rs11196205(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 10 |
| Position | 113047288 |
| Gene | TCF7L2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11196205 |
| dbSNP (classic) | rs11196205 |
| ClinGen | rs11196205 |
| ebi | rs11196205 |
| HLI | rs11196205 |
| Exac | rs11196205 |
| Gnomad | rs11196205 |
| Varsome | rs11196205 |
| LitVar | rs11196205 |
| Map | rs11196205 |
| PheGenI | rs11196205 |
| Biobank | rs11196205 |
| 1000 genomes | rs11196205 |
| hgdp | rs11196205 |
| ensembl | rs11196205 |
| geneview | rs11196205 |
| scholar | rs11196205 |
| rs11196205 | |
| pharmgkb | rs11196205 |
| gwascentral | rs11196205 |
| openSNP | rs11196205 |
| 23andMe | rs11196205 |
| SNPshot | rs11196205 |
| SNPdbe | rs11196205 |
| MSV3d | rs11196205 |
| GWAS Ctlg | rs11196205 |
| GMAF | 0.4197 |
| Max Magnitude | 0 |
| ? | (C;C) (C;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 17340123] rs12255372, rs7903146, rs7901695 and rs11196205 associated with type-2 diabetes
[PMID 20028944
] Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a risk population for type 2 diabetes
[PMID 22441719] Stronger Association of Common Variants in TCF7L2 Gene with Nonobese Type 2 Diabetes in the Latvian Population
[PMID 22511877] Type 2 Diabetes Risk Alleles Demonstrate Extreme Directional Differentiation among Human Populations, Compared to Other Diseases
[PMID 16936218] Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.
[PMID 17245589] A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.
[PMID 17311858] TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.
[PMID 17601994] Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.
[PMID 17609304] Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese.
[PMID 17661009] Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.
[PMID 17934151] A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.
[PMID 17971425] Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.
[PMID 18097733] Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects.
[PMID 18268068] Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study.
[PMID 18291022] Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.
[PMID 18397358] TCF7L2 polymorphisms are associated with type 2 diabetes in Khatri Sikhs from North India: genetic variation affects lipid levels.
[PMID 18437354] TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.
[PMID 18598350] Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
[PMID 18650481] TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.
[PMID 18655717] Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.
[PMID 19228405] Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.
[PMID 19482368] Meta-analysis of the association between SNPs in TCF7L2 and type 2 diabetes in East Asian population.
[PMID 19924244] TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.
[PMID 21133856] Genome-wide association scan allowing for epistasis in type 2 diabetes.
[PMID 21159844] Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.
[PMID 21423583] Single nucleotide polymorphisms of TCF7L2 are linked to diabetic coronary atherosclerosis.
[PMID 23041303] Association between donor and recipient TCF7L2 gene polymorphisms and the risk of new-onset diabetes mellitus after liver transplantation in a Han Chinese population
[PMID 23577093] Association of TCF7L2 Gene Polymorphisms with T2DM in the Population of Hyderabad, India
[PMID 23188737] TCF7L2 gene polymorphisms and type 2 diabetes risk: a comprehensive and updated meta-analysis involving 121,174 subjects
[PMID 23107111] Transcription factor-7-like 2 gene variants are strongly associated with type 2 diabetes in Lebanese subjects.
[PMID 25274455] The gene polymorphisms of UCP1 but not PPAR γ and TCF7L2 are associated with diabetic retinopathy in Chinese type 2 diabetes mellitus cases
| ClinVar | |
|---|---|
| Risk | rs11196205(C;C) rs11196205(T;T) |
| Alt | rs11196205(C;C) rs11196205(T;T) |
| Reference | rs11196205(G;G) |
| Significance | Other |
| Disease | Diabetes mellitus type 2 |
| Variation | info |
| Gene | TCF7L2 |
| CLNDBN | Diabetes mellitus type 2 |
| Reversed | 0 |
| HGVS | NC_000010.10:g.114807047G>C |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000007840.2, |
[PMID 30858716] Interaction between dietary patterns and TCF7L2 polymorphisms on type 2 diabetes mellitus among Uyghur adults in Xinjiang Province, China.
