rs1126742
Orientation | minus |
Stabilized | minus |
Geno | Mag | Summary |
---|---|---|
(C;C) | normal | |
(C;T) | higher hypertension risk | |
(T;T) | 0 | higher hypertension risk |
Reference | GRCh38 38.1/141 |
Chromosome | 1 |
Position | 46932824 |
Gene | CYP4A11 |
is a | snp |
is | mentioned by |
dbSNP | rs1126742 |
dbSNP (classic) | rs1126742 |
ClinGen | rs1126742 |
ebi | rs1126742 |
HLI | rs1126742 |
Exac | rs1126742 |
Gnomad | rs1126742 |
Varsome | rs1126742 |
LitVar | rs1126742 |
Map | rs1126742 |
PheGenI | rs1126742 |
Biobank | rs1126742 |
1000 genomes | rs1126742 |
hgdp | rs1126742 |
ensembl | rs1126742 |
geneview | rs1126742 |
scholar | rs1126742 |
rs1126742 | |
pharmgkb | rs1126742 |
gwascentral | rs1126742 |
openSNP | rs1126742 |
23andMe | rs1126742 |
SNPshot | rs1126742 |
SNPdbe | rs1126742 |
MSV3d | rs1126742 |
GWAS Ctlg | rs1126742 |
GMAF | 0.174 |
Max Magnitude | 0 |
rs1126742 is a SNP in the CYP4A11 gene, which encodes an enzyme that converts arachidonic acid to 20-hydroxyeicosatetraenoic acid, a metabolite involved in blood pressure regulation in humans.
In a study of 304 Japanese hypertension patients, rs1126742(C;T) and (T;T) genotypes were significantly (p=0.022) higher than in control individuals.[PMID 18300855]
[PMID 18484194] Haplotype-based case study of human CYP4A11 gene and cerebral infarction in Japanese subject.
[PMID 22327816] A Novel Polymorphism of the CYP4A11 Gene is Associated With Coronary Artery Disease.
[PMID 22804341] Haplotype-based case-control study of CYP4A11 gene and myocardial infarction
[PMID 24164311] CYP4A11 gene T8590C polymorphism is associated with essential hypertension in the male western Chinese Han population
[PMID 23085321] Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China.
[PMID 28534704] Associations of CYP4A11 gene-gene and gene-smoking interactions with essential hypertension in the male eastern Chinese Han population.