rs1143627
| Orientation | minus |
| Stabilized | minus |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | common in clinvar |
| Make rs1143627(C;T) |
| Make rs1143627(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 112836810 |
| Gene | IL1B |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1143627 |
| dbSNP (classic) | rs1143627 |
| ClinGen | rs1143627 |
| ebi | rs1143627 |
| HLI | rs1143627 |
| Exac | rs1143627 |
| Gnomad | rs1143627 |
| Varsome | rs1143627 |
| LitVar | rs1143627 |
| Map | rs1143627 |
| PheGenI | rs1143627 |
| Biobank | rs1143627 |
| 1000 genomes | rs1143627 |
| hgdp | rs1143627 |
| ensembl | rs1143627 |
| geneview | rs1143627 |
| scholar | rs1143627 |
| rs1143627 | |
| pharmgkb | rs1143627 |
| gwascentral | rs1143627 |
| openSNP | rs1143627 |
| 23andMe | rs1143627 |
| SNPshot | rs1143627 |
| SNPdbe | rs1143627 |
| MSV3d | rs1143627 |
| GWAS Ctlg | rs1143627 |
| GMAF | 0.4803 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 16508980] associated with ankylosing spondylitis
[PMID 16961803] risk of Helicobacter pylori infection. Children carrying IL1A-889T had a lower risk of H. pylori positivity, compared to those carrying -889C, with each T allele associated with 43% risk reduction (OR = 0.57, 95% CI = 0.33-0.99, p-trend = .05)
upregulation of pro-inflammatory cytokines may protect against persistent H. pylori colonization.
[PMID 19280228] Interleukin-1 cluster gene polymorphisms in childhood IgA nephropathy
[PMID 19733643] Interleukin-1 region meta-analysis with osteoarthritis phenotypes
[PMID 19793334
] Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells
[PMID 20509889] The polymorphism rs3024505 proximal to IL-10 is associated with risk of ulcerative colitis and Crohns disease in a Danish case-control study
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 21992747] Pharmacogenetic analysis of the effects of polymorphisms in APOE, IDE and IL1B on a ketone body based therapeutic on cognition in mild to moderate Alzheimer's disease; a randomized, double-blind, placebo-controlled study
[PMID 21968104] The association of genetic variants in interleukin-1 genes with cognition: findings from the cardiovascular health study
[PMID 16078996] Association study of functional genetic variants of innate immunity related genes in celiac disease.
[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
[PMID 17356794] Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract.
[PMID 17532232] Potential influence of IL1B haplotype and IL1A-IL1B-IL1RN extended haplotype on hand osteoarthritis risk.
[PMID 17592300] Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype.
[PMID 17601350] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
[PMID 18464913] A genome-wide association study identifies protein quantitative trait loci (pQTLs).
[PMID 18576312] A broad analysis of IL1 polymorphism and rheumatoid arthritis.
[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
[PMID 18757527] Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer.
[PMID 18842150] Concurrent genotyping of Helicobacter pylori virulence genes and human cytokine SNP sites using whole genome amplified DNA derived from minute amounts of gastric biopsy specimen DNA.
[PMID 19016479] Tagging SNP association study of the IL-1beta gene (IL1B) and childhood-onset mood disorders.
[PMID 19043479] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19092239] Common variants in interleukin-1-Beta gene are associated with intracranial hemorrhage and susceptibility to brain arteriovenous malformation.
[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
[PMID 19734419] A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support.
[PMID 20012999] The cancer anorexia/weight loss syndrome: exploring associations with single nucleotide polymorphisms (SNPs) of inflammatory cytokines in patients with non-small cell lung cancer.
[PMID 20437198] Three polymorphisms in interleukin-1beta gene and risk for breast cancer: a meta-analysis.
[PMID 20463618] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.
[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.
[PMID 21111021] Toll-like receptors and cytokines/cytokine receptors polymorphisms associate with non-response to hepatitis B vaccine.
[PMID 21172166] Pharmacogenetics of antidepressant response.
[PMID 21240526] Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review.
[PMID 21385363] Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study.
[PMID 21448414] Molecular mechanism of glucocorticoid resistance in inflammatory bowel disease.
[PMID 21880580] Interaction between functional polymorphic variants in cytokine genes, established risk factors and susceptibility to basal cell carcinoma of skin.
[PMID 23592922] Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population
[PMID 24194923] Interactions between Diet, Lifestyle and IL10, IL1B, and PTGS2/COX-2 Gene Polymorphisms in Relation to Risk of Colorectal Cancer in a Prospective Danish Case-Cohort Study
[PMID 23927441] Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus
[PMID 22858724] IL1B and VWF variants are associated with fibrinolytic early recanalization in patients with ischemic stroke.
[PMID 23029430] Prognostic role of host cyclooxygenase and cytokine genotypes in a Caucasian cohort of patients with gastric adenocarcinoma.
[PMID 25222025] Interleukin-1β-31C/T and -511T/C Polymorphisms Were Associated with Preeclampsia in Chinese Han Population
[PMID 25304949] Role of Genetic Polymorphisms in NFKB-Mediated Inflammatory Pathways in Response to Primary Chemoradiation Therapy for Rectal Cancer
[PMID 25374200] Genetic Polymorphism of Interleukin-1A (IL-1A), IL-1B, and IL-1 Receptor Antagonist (IL-1RN) and Prostate Cancer Risk
[PMID 25446437] Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population
| ClinVar | |
|---|---|
| Risk | rs1143627(T;T) |
| Alt | rs1143627(T;T) |
| Reference | Rs1143627(C;C) |
| Significance | Other |
| Disease | Gastric cancer susceptibility after h. pylori infection |
| Variation | info |
| Gene | IL1B |
| CLNDBN | Gastric cancer susceptibility after h. pylori infection |
| Reversed | 1 |
| HGVS | NC_000002.11:g.113594387G>A |
| CLNSRC | OMIM Allelic Variant |
| CLNACC | RCV000015783.26, |
[PMID 26141218] IL1B gene polymorphisms, age and the risk of non-small cell lung cancer in a Chinese population
[PMID 26200829] Association of Interleukin-1 Gene Single Nucleotide Polymorphisms with Keratoconus in Chinese Han Population
[PMID 26846412] Ancestry informative markers and selected single nucleotide polymorphisms in immunoregulatory genes on preterm labor and preterm premature rupture of membranes: a case control study.
[PMID 27159547] Adipokine Gene Single-Nucleotide Polymorphisms in Portuguese Obese Adolescents: Associations with Plasma Concentrations of Adiponectin, Resistin, IL-6, IL-1β, and TNF-α.
[PMID 27602547] Impact of IL1B gene polymorphisms and interleukin 1B levels on susceptibility to spontaneous preterm birth.
[PMID 28268030] Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study.
[PMID 31046486] The study of methylation and single nucleotide polymorphisms of cancer-related genes in patients with early-stage ulcerative colitis.
[PMID 32124801] SNPs and transcriptional activity of genes of innate and adaptive immunity at the maternal-fetal interface in woman with preterm labour, associated with preterm premature rupture of membranes.
[PMID 32391643] Evaluation of genetic variants in IL-1B and its interaction with the predisposition of osteoporosis in the northwestern Chinese Han population.
