rs11718863

plus

Geno	Mag	Summary
(A;A)	0	normal
(A;T)		1.43x increased osteoarthritis risk
(T;T)		1.43x increased osteoarthritis risk

Reference

GRCh38 38.1/141

Chromosome

3

Position

15175196

Gene

COL6A4P1

is a	snp
is	mentioned by
dbSNP	rs11718863
dbSNP (classic)	rs11718863
ClinGen	rs11718863
ebi	rs11718863
HLI	rs11718863
Exac	rs11718863
Gnomad	rs11718863
Varsome	rs11718863
LitVar	rs11718863
Map	rs11718863
PheGenI	rs11718863
Biobank	rs11718863
1000 genomes	rs11718863
hgdp	rs11718863
ensembl	rs11718863
geneview	rs11718863
scholar	rs11718863
google	rs11718863
pharmgkb	rs11718863
gwascentral	rs11718863
openSNP	rs11718863
23andMe	rs11718863
SNPshot	rs11718863
SNPdbe	rs11718863
MSV3d	rs11718863
GWAS Ctlg	rs11718863

GMAF

0.2305

Max Magnitude

0

?

(A;A) (A;T) (T;T)

28

rs11718863 is one of several SNPs in the DVWA gene found to be associated with osteoarthritis based on a study of several Japanese patient populations. The allelic odds ratio is 1.43 (CI: 1.26-1.63, p = 5.2 x 10e-8) for the minor allele, which is the (T) allele (in dbSNP orientation). [PMID 18622395]

OMIM	612401
Desc	OSTEOARTHRITIS SUSCEPTIBILITY 6; OS6
Variant
Related	also

[PMID 20238217] Lack of evidence for association between DVWA gene polymorphisms and developmental dysplasia of the hip in Chinese Han population

[PMID 19054821] Association of the DVWA and GDF5 polymorphisms with osteoarthritis in UK populations.

[PMID 19181678] Large replication study and meta-analyses of DVWA as an osteoarthritis susceptibility locus in European and Asian populations.

[PMID 26550167 ] The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis