rs11889341
| Orientation | plus |
| Stabilized | plus |
| Make rs11889341(C;C) |
| Make rs11889341(C;T) |
| Make rs11889341(T;T) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 2 |
| Position | 191079016 |
| Gene | STAT4 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs11889341 |
| dbSNP (classic) | rs11889341 |
| ClinGen | rs11889341 |
| ebi | rs11889341 |
| HLI | rs11889341 |
| Exac | rs11889341 |
| Gnomad | rs11889341 |
| Varsome | rs11889341 |
| LitVar | rs11889341 |
| Map | rs11889341 |
| PheGenI | rs11889341 |
| Biobank | rs11889341 |
| 1000 genomes | rs11889341 |
| hgdp | rs11889341 |
| ensembl | rs11889341 |
| geneview | rs11889341 |
| scholar | rs11889341 |
| rs11889341 | |
| pharmgkb | rs11889341 |
| gwascentral | rs11889341 |
| openSNP | rs11889341 |
| 23andMe | rs11889341 |
| SNPshot | rs11889341 |
| SNPdbe | rs11889341 |
| MSV3d | rs11889341 |
| GWAS Ctlg | rs11889341 |
| GMAF | 0.2456 |
| Max Magnitude | 0 |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 19737838] A haplotype in STAT4 gene associated with rheumatoid arthritis in Caucasians is not associated in the Han Chinese population, but with the presence of rheumatoid factor
[PMID 19950257
] Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: Evidence of possible gene-gene interaction and alterations in Th1/Th2 cytokines
[PMID 20176035] Association of signal transducer and activator of transcription 4 genetic variants with extra-intestinal manifestations in inflammatory bowel disease
[PMID 21683716] Signal transducer and activator of transcription 4 gene polymorphisms associated with rheumatoid arthritis in Northwestern Chinese Han population
[PMID 22483685] Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population
[PMID 17932559] Association of STAT4 with rheumatoid arthritis in the Korean population.
[PMID 18434327] Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility.
[PMID 18516230] Specificity of the STAT4 genetic association for severe disease manifestations of systemic lupus erythematosus.
[PMID 18579578] A risk haplotype of STAT4 for systemic lupus erythematosus is over-expressed, correlates with anti-dsDNA and shows additive effects with two risk alleles of IRF5.
[PMID 18803832] Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.
[PMID 19674979] Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
[PMID 20454450] Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
[PMID 22569826] Abnormal Genetic and Epigenetic Changes in Signal Transducer and Activator of Transcription 4 in the Pathogenesis of Inflammatory Bowel Diseases.
[PMID 24059108] [Signal transducer and activator of transcription 4 gene polymorphisms associated with dilated cardiomyopathy in Chinese Han population]
[PMID 24386384] Association of STAT4 Polymorphism with Severe Renal Insufficiency in Lupus Nephritis
| GWAS snp | |
|---|---|
| PMID | [PMID 24390342]
|
| Trait | Rheumatoid arthritis |
| Title | Genetics of rheumatoid arthritis contributes to biology and drug discovery. |
| Risk Allele | T |
| P-val | 4E-19 |
| Odds Ratio | 1.13 [1.10-1.17] |
