rs12026

minus

Geno	Mag	Summary
(C;C)	0	common in clinvar

Make rs12026(C;G)

Make rs12026(G;G)

Reference

GRCh38 38.1/141

Chromosome

7

Position

95411704

Gene

PON2

is a	snp
is	mentioned by
dbSNP	rs12026
dbSNP (classic)	rs12026
ClinGen	rs12026
ebi	rs12026
HLI	rs12026
Exac	rs12026
Gnomad	rs12026
Varsome	rs12026
LitVar	rs12026
Map	rs12026
PheGenI	rs12026
Biobank	rs12026
1000 genomes	rs12026
hgdp	rs12026
ensembl	rs12026
geneview	rs12026
scholar	rs12026
google	rs12026
pharmgkb	rs12026
gwascentral	rs12026
openSNP	rs12026
23andMe	rs12026
SNPshot	rs12026
SNPdbe	rs12026
MSV3d	rs12026
GWAS Ctlg	rs12026

Merged from

0.2548

0

(C;C) (C;G) (G;G)

28

[PMID 9329371] reports that one or two copies of a common variation (glycine replacing alanine) present at amino acid 148 of the PON2 protein, rs12026, exacerbates glycemia in non-insulin dependent diabetes mellitus (NIDDM).

OMIM	602447
Desc
Variant	0002
Related	also

ClinVar
Risk	rs12026(G;G)
Alt	rs12026(G;G)
Reference	Rs12026(C;C)
Significance	Non-pathogenic
Disease	PARAOXONASE 2 POLYMORPHISM
Variation	info
Gene	PON2
CLNDBN	PARAOXONASE 2 POLYMORPHISM
Reversed	1
HGVS	NC_000007.13:g.95041016G>C
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000007501.2,

[PMID 17601350 ] A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.

[PMID 21223581 ] Association analysis of PON2 genetic variants with serum paraoxonase activity and systemic lupus erythematosus.

[PMID 23327886] Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the Chinese population.

[PMID 24100645] Association of paraoxonase gene polymorphisms with diabetic nephropathy and retinopathy

[PMID 24148949] [Association between single nucleotide polymorphisms of PON2 gene and susceptibility to occupational noise-induced deafness among Chinese Han population exposed to high noise levels]