PON2
| is a | gene |
| is | mentioned by |
| Full name | paraoxonase 2 |
| EntrezGene | 5445 |
| PheGenI | 5445 |
| VariationViewer | 5445 |
| ClinVar | PON2 |
| GeneCards | PON2 |
| dbSNP | 5445 |
| Diseases | PON2 |
| SADR | 5445 |
| HugeNav | 5445 |
| wikipedia | PON2 |
| PON2 | |
| gopubmed | PON2 |
| EVS | PON2 |
| HEFalMp | PON2 |
| MyGene2 | PON2 |
| 23andMe | PON2 |
| UniProt | Q15165 |
| Ensembl | ENSG00000105854 |
| OMIM | 602447 |
| # SNPs | 16 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs11981433 | 0 | 95,425,028 | |
| rs11982486 | 0 | 95,426,286 | |
| rs12026 | 0 | 95,411,704 | |
| rs12704795 | 0 | 95,424,695 | |
| rs13306702 | 0 | 95,404,734 | |
| rs17166879 | 0 | 95,424,103 | |
| rs17876088 | 0 | 95,424,695 | |
| rs17876142 | 0 | 95,411,704 | |
| rs17876183 | 0 | 95,434,956 | |
| rs17876205 | 0 | 95,403,792 | |
| rs4729189 | 0 | 95,428,647 | |
| rs6954345 | 0 | 95,405,463 | |
| rs7493 | 0 | 95,405,463 | |
| rs7785846 | 0 | 95,404,529 | |
| rs7786401 | 0 | 95,404,689 | |
| rs987539 | 0 | 95,407,680 |
Like PON1, variations in PON2, the paraoxonase 2 gene, have been linked to several medical conditions.
Paraoxonases are esterases, a complex family of enzymes involved in breaking down chemicals including several types of pesticides and pharmaceutical drugs, and also involved in protecting both high- and low-density lipoproteins from oxidation. Individuals with less paraoxonase activity appear to be more susceptible to Heart disease, pesticide poisoning, atherosclerosis and Diabetes.
[PMID 16822964] rs12704795, originally known as rs17876088 is associated with ALS (Lou Gehrig's). This variation occurs in the PON2 gene, which encodes a protein involved in the detoxification of certain environmental toxins.
[PMID 9329371] reports that a common variation present at amino acid 148 of the PON2 protein, rs12026, exacerbates glycemia in non-insulin dependent diabetes mellitus (NIDDM).
[PMID 19840942] reports that inheriting the Cys form encoded by PON2 rs7493 results in impaired lactonase activity.
