rs12603332 is a SNP near the ORMDL3 gene, which has been linked in several studies to asthma.
[PMID 18310477] 264 African American asthma subjects and 176 healthy controls. (p = 0.028 and 0.001 for rs4378650 and p = 0.021 and 0.001 for rs12603332), and a trend towards association in Puerto Ricans (p = 0.076 and 0.080 for SNPs rs4378650 and rs12603332, respectively)
[PMID 21843571] Relationship between the 17q21 locus and adult asthma in a Czech population
[PMID 22370936] Genetic variants on 17q21 are associated with asthma in a Han Chinese population
[PMID 19732864] Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
[PMID 30644696] Investigating the Association of Orosomucoid 1-like 3 (ORMDL3) Gene Polymorphism (rs12603332) with Susceptibility to Allergic Asthma in Iranian Northwestern Azeri Population.