rs140701

minus

Geno	Mag	Summary
(A;A)	1.5	Increased risk for anxiety disorders
(A;G)	1.5	Increased risk for anxiety disorders
(G;G)	1	Normal risk for anxiety disorders

Reference

GRCh38 38.1/142

Chromosome

17

Position

30211514

Gene

SLC6A4

is a	snp
is	mentioned by
dbSNP	rs140701
dbSNP (classic)	rs140701
ClinGen	rs140701
ebi	rs140701
HLI	rs140701
Exac	rs140701
Gnomad	rs140701
Varsome	rs140701
LitVar	rs140701
Map	rs140701
PheGenI	rs140701
Biobank	rs140701
1000 genomes	rs140701
hgdp	rs140701
ensembl	rs140701
geneview	rs140701
scholar	rs140701
google	rs140701
pharmgkb	rs140701
gwascentral	rs140701
openSNP	rs140701
23andMe	rs140701
SNPshot	rs140701
SNPdbe	rs140701
MSV3d	rs140701
GWAS Ctlg	rs140701

GMAF

0.4862

Max Magnitude

1.5

?

(A;A) (A;G) (G;G)

28

A study of patients with panic disorder or social anxiety disorder, both moderately heritable anxiety disorders, concluded that the rs140701(A) allele was associated with increased risk for both disorders. This SNP was actually part of a tightly linked haplotype A-A-G (for SNPs rs3794808, rs140701 and rs4583306, respectively) that had 1.7x increased risk for panic disorder (CI: 1.2-2.3).[PMID 18663369 ]

[PMID 20180013] Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women

[PMID 20502016] Polymorphism C in the Serotonin Transporter Gene in Depression-Free Elderly Patients with Vascular Dementia

[PMID 15361494 ] Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women.

[PMID 16848906 ] Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.

[PMID 17629953] Loudness dependence of auditory evoked potentials is not associated with polymorphisms or haplotypes in the serotonin transporter gene in a community-based sample of German healthy volunteers.

[PMID 19141529 ] Serotonin transporter polymorphisms in patients with portopulmonary hypertension.

[PMID 19184136 ] Examination of association of genes in the serotonin system to autism.

[PMID 19351213] Development and validation of a high-throughput screening method for two polymorphisms in the serotonin transporter gene.

[PMID 19772600 ] A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data.

[PMID 19844206 ] Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans.

[PMID 22727904] Sex determines which section of the SLC6A4 gene is linked to obsessive-compulsive symptoms in normal Chinese college students.

[PMID 26408209] Common variants of HTR1A and SLC6A4 confer the increasing risk of Schizophrenia susceptibility: A population-based association and epistasis analysis

[PMID 28272115] Further evidence for genetic variation at the serotonin transporter gene SLC6A4 contributing toward anxiety.