rs1535
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | ||
| (A;G) | 4+ IQ points for breastfeeding | |
| (G;G) | 0 | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 11 |
| Position | 61830500 |
| Gene | FADS2 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1535 |
| dbSNP (classic) | rs1535 |
| ClinGen | rs1535 |
| ebi | rs1535 |
| HLI | rs1535 |
| Exac | rs1535 |
| Gnomad | rs1535 |
| Varsome | rs1535 |
| LitVar | rs1535 |
| Map | rs1535 |
| PheGenI | rs1535 |
| Biobank | rs1535 |
| 1000 genomes | rs1535 |
| hgdp | rs1535 |
| ensembl | rs1535 |
| geneview | rs1535 |
| scholar | rs1535 |
| rs1535 | |
| pharmgkb | rs1535 |
| gwascentral | rs1535 |
| openSNP | rs1535 |
| 23andMe | rs1535 |
| SNPshot | rs1535 |
| SNPdbe | rs1535 |
| MSV3d | rs1535 |
| GWAS Ctlg | rs1535 |
| GMAF | 0.3494 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
| GWAS snp | |
|---|---|
| PMID | [PMID 20339536 ]
|
| Trait | Response to statin therapy |
| Title | Genome-wide association of lipid-lowering response to statins in combined study populations |
| Risk Allele | G |
| P-val | 0.000007 |
| Odds Ratio | None None |
Publications[edit]
Breast feeding and IQ[edit]
[PMID 30541029] Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis.
[PMID 27311901] Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: protocol for a collaborative meta-analysis. (Erratum / Correction)
[PMID 21156270] Cognitive function in adolescence: testing for interactions between breast-feeding and FADS2 polymorphisms.
[PMID 20644632] FADS2 Polymorphisms Modify the Effect of Breastfeeding on Child IQ
[PMID 17984066] Moderation of breastfeeding effects on the IQ by genetic variation in fatty acid metabolism. (4+ IQ points for breastfeeding with the AA or AG genotypes)
Other publications[edit]
| GWAS snp | |
|---|---|
| PMID | [PMID 20694148]
|
| Trait | |
| Title | A genome-wide association study of the metabolic syndrome in Indian Asian men |
| Risk Allele | G |
| P-val | 4E-7 |
| Odds Ratio | 0.03 [0.02-0.04] mmol/l decrease |
| GWAS snp | |
|---|---|
| PMID | [PMID 21829377]
|
| Trait | |
| Title | Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium. |
| Risk Allele | A |
| P-val | 0 |
| Odds Ratio | 0.0700 [NR] % increase |
[PMID 23861364] Do Genetic Modifiers of HDL-C and Triglyceride Levels also Modify Their Response to a Lifestyle Intervention in the Setting of Obesity and Type-2 Diabetes Mellitus? The Look AHEAD Study
[PMID 23737301] A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems.
[PMID 23636240] FADS genotype and diet are important determinants of DHA status: a cross-sectional study in Danish infants.
[PMID 22743310] Circulating and dietary alpha-linolenic acid and incidence of congestive heart failure in older adults: the Cardiovascular Health Study.
[PMID 22194195] Polyunsaturated fatty acid levels in blood during pregnancy, at birth and at 7 years: their associations with two common FADS2 polymorphisms.
[PMID 21347282] Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.
[PMID 19798445] Genetic determinants of circulating sphingolipid concentrations in European populations.
[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
[PMID 31991592] Genome-Wide Association Study for Serum Omega-3 and Omega-6 Polyunsaturated Fatty Acids: Exploratory Analysis of the Sex-Specific Effects and Dietary Modulation in Mediterranean Subjects with Metabolic Syndrome.
