rs1570360
| Orientation | plus |
| Stabilized | plus |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 3x risk | |
| (A;G) | 3x risk | |
| (G;G) | normal |
| Reference | GRCh38 38.1/141 |
| Chromosome | 6 |
| Position | 43770093 |
| Gene | VEGFA |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1570360 |
| dbSNP (classic) | rs1570360 |
| ClinGen | rs1570360 |
| ebi | rs1570360 |
| HLI | rs1570360 |
| Exac | rs1570360 |
| Gnomad | rs1570360 |
| Varsome | rs1570360 |
| LitVar | rs1570360 |
| Map | rs1570360 |
| PheGenI | rs1570360 |
| Biobank | rs1570360 |
| 1000 genomes | rs1570360 |
| hgdp | rs1570360 |
| ensembl | rs1570360 |
| geneview | rs1570360 |
| scholar | rs1570360 |
| rs1570360 | |
| pharmgkb | rs1570360 |
| gwascentral | rs1570360 |
| openSNP | rs1570360 |
| 23andMe | rs1570360 |
| SNPshot | rs1570360 |
| SNPdbe | rs1570360 |
| MSV3d | rs1570360 |
| GWAS Ctlg | rs1570360 |
| GMAF | 0.2241 |
| Max Magnitude | 0 |
This position is referred to as the -1154 position in many VEGF-associated publications. The normal (or wild type) form of this SNP is a (G). The (A) form reduces the activity of this gene, resulting in less VEGF protein.
Individuals with one or more rs1570360(A) alleles are reported to be at about a 3 fold higher risk of developing Sudden Infant Death Syndrome [PMID 16916659].
[PMID 19429179] Association between promoter polymorphisms of vascular endothelial growth factor gene and sporadic Alzheimer's disease among Northern Chinese Han
[PMID 19308252
] Genetic variation in VEGF does not contribute significantly to the risk of congenital cardiovascular malformation
[PMID 19594543] Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer
[PMID 20082870] A Single Nucleotide Polymorphism in the Vascular Endothelial Growth Factor Gene Is Associated with Recurrence of Hepatocellular Carcinoma after Transplantation
[PMID 19233472] Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection
[PMID 20132989] Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
[PMID 20678803] Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration
[PMID 20950367] Association of Vascular Endothelial Growth Factor Gene Polymorphisms with Recurrent Spontaneous Abortion in Chinese Han Women
[PMID 22015057] Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study
[PMID 22167330] Polymorphism of vascular endothelial growth factor -1154G>A (rs1570360) with cancer risk: a meta-analysis of 16 case-control studies
[PMID 22818823] Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients
[PMID 16142870] A functional variant of vascular endothelial growth factor is associated with severe ischemic complications in giant cell arteritis.
[PMID 16216669] Analysis of vascular endothelial growth factor (VEGF) functional variants in rheumatoid arthritis.
[PMID 16395752] Association between functional haplotypes of vascular endothelial growth factor and renal complications in Henoch-Schonlein purpura.
[PMID 16613616] Polymorphisms in the vascular endothelial growth factor gene and breast cancer in the Cancer Prevention Study II cohort.
[PMID 16685110] Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
[PMID 16801663] Possible gender-dependent association of vascular endothelial growth factor (VEGF) gene and ALS.
[PMID 17204151] VEGF, FGF1, FGF2 and EGF gene polymorphisms and psoriatic arthritis.
[PMID 17319747] Large-scale evaluation of candidate genes identifies associations between VEGF polymorphisms and bladder cancer risk.
[PMID 17625508] VEGF C-634G polymorphism is associated with protection from isolated ventricular septal defect: case-control and TDT studies.
[PMID 18441306] VEGF polymorphisms are associated with severity of diabetic retinopathy.
[PMID 19551141] Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.
[PMID 19587357] A systematic meta-analysis of genetic association studies for diabetic retinopathy.
[PMID 19603096] An analysis of growth, differentiation and apoptosis genes with risk of renal cancer.
[PMID 19755511] The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors.
[PMID 19842071] No association of VEGF polymorphims with Alzheimer's disease.
[PMID 20140301] VEGFA polymorphisms and cardiovascular anomalies in 22q11 microdeletion syndrome: a case-control and family-based study.
[PMID 20389299] Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.
[PMID 20444917] Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy.
[PMID 20706635] Human genetics of diabetic retinopathy: current perspectives.
[PMID 21080079] Gene polymorphism of vascular endothelial growth factor -1154 G>A is associated with hypertensive nephropathy in a Hispanic population.
[PMID 21257617] Association of polymorphisms/haplotypes of the genes encoding vascular endothelial growth factor and its KDR receptor with recurrent pregnancy loss.
[PMID 21347390] Genetics of VEGF serum variation in human isolated populations of cilento: importance of VEGF polymorphisms.
[PMID 21388351] Vascular endothelial growth factor A and cardiovascular disease in rheumatoid arthritis patients.
[PMID 21982816] Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population.
[PMID 23211130] Polymorphisms in the vascular endothelial growth factor gene associated with recurrent spontaneous miscarriage
[PMID 23404364] Polymorphisms in the VEGFA promoter are associated with susceptibility to hepatocellular carcinoma by altering promoter activity
[PMID 24177231] The RTK/ERK Pathway is associated with Prostate Cancer Risk on the SNP level: a pooled analysis of 41 sets of data from case-control studies
[PMID 24321896] Effect of Genetic Polymorphisms of Vascular Endothelial Growth Factor on Left Ventricular Hypertrophy in Patients With Systemic Hypertension
[PMID 22729570] AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.
[PMID 22925497] The relation of vascular endothelial growth factor (VEGF) gene polymorphisms on VEGF levels and the risk of vasoocclusive crisis in sickle cell disease.
[PMID 23007311] VEGF genetic polymorphisms affect the responsiveness to sildenafil in clinical and postoperative erectile dysfunction.
[PMID 23545315] Further evidence for the contribution of the vascular endothelial growth factor gene in coronary artery disease susceptibility.
[PMID 23553563] VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau.
[PMID 24868559] The Associations between VEGF Gene Polymorphisms and Diabetic Retinopathy Susceptibility: A Meta-Analysis of 11 Case-Control Studies
[PMID 24935327] Haplotype Analysis on Chromosome 6p of Tumor Necrosis Factor Alpha, Vascular Endothelial Growth Factor A, and Interleukin-17F Alleles Associated With Corneal Transplant Rejection
[PMID 24940484] Association between vascular endothelial growth factor gene polymorphisms and bladder cancer risk
[PMID 25148899] Investigating the association of vascular endothelial growth factor polymorphisms with breast cancer: a Moroccan case-control study
[PMID 25894981] Genetic Variations of VEGF Gene Were Associated with Tetralogy of Fallot Risk in a Chinese Han Population
[PMID 26002049] Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril
[PMID 26264619] Vascular endothelial growth factor polymorphisms and a synchronized examination of plasma and tissue expression in epithelial ovarian cancers
[PMID 26305668] The Relationship between Vascular Endothelial Growth Factor 1154G/A Polymorphism and Recurrent Implantation Failure
[PMID 26486233] Vascular endothelial growth factor (VEGF)-634G/C polymorphism was associated with severe pre-eclampsia and lower serum VEGF level
[PMID 28651127] Vascular endothelial growth factor single nucleotide polymorphisms and haplotypes in pre-eclampsia: A case-control study.
[PMID 27766947] Vascular endothelial growth factor (VEGFA) gene variation in polycystic ovary syndrome in a Tunisian women population.
[PMID 29054076] Genetic polymorphisms in angiogenesis-related genes are associated with worse progression-free survival of patients with advanced gastrointestinal stromal tumours treated with imatinib.
[PMID 32997825] VEGFR2 and VEGFA polymorphism are not associated with an inferior prognosis in Caucasian patients with aggressive B-cell lymphoma.
